Literature DB >> 10559938

The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor.

P M Lembo1, E Grazzini, J Cao, D A Hubatsch, M Pelletier, C Hoffert, S St-Onge, C Pou, J Labrecque, T Groblewski, D O'Donnell, K Payza, S Ahmad, P Walker.   

Abstract

Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we identify MCH as the ligand for the orphan receptor SLC-1. The rat SLC-1 is activated by nanomolar concentrations of MCH and is coupled to the G protein G alpha i/o. The pattern of SLC-1 messenger RNA expression coincides with the distribution of MCH-containing nerve terminals and is consistent with the known central effects of MCH. Our identification of an MCH receptor could have implications for the development of new anti-obesity therapies.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10559938     DOI： 10.1038/12978

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  61 in total

1.  Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus.

Authors:  X B Gao; A N van den Pol
Journal:  J Physiol       Date:  2001-05-15       Impact factor: 5.182

2.  Melanin-concentrating hormone depresses L-, N-, and P/Q-type voltage-dependent calcium channels in rat lateral hypothalamic neurons.

Authors:  Xiao-Bing Gao; Anthony N van den Pol
Journal:  J Physiol       Date:  2002-07-01       Impact factor: 5.182

Review 3.  Orphan GPCR research.

Authors:  S Chung; T Funakoshi; O Civelli
Journal:  Br J Pharmacol       Date:  2007-12-10       Impact factor: 8.739

Review 4.  Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking.

Authors:  Uri Shalev; Suzanne Erb; Yavin Shaham
Journal:  Brain Res       Date:  2009-07-23       Impact factor: 3.252

5.  Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction.

Authors:  Min Wu; Iryna Dumalska; Elena Morozova; Anthony van den Pol; Meenakshi Alreja
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-21       Impact factor: 11.205

6.  Norbin: A promising central nervous system regulator.

Authors:  Hong Wang; Yi Nong; Fernando Bazan; Paul Greengard; Marc Flajolet
Journal:  Commun Integr Biol       Date:  2010-11-01

7.  Microinjections of melanin concentrating hormone into the nucleus tractus solitarius of the rat elicit depressor and bradycardic responses.

Authors:  S N Brown; V C Chitravanshi; K Kawabe; H N Sapru
Journal:  Neuroscience       Date:  2007-10-05       Impact factor: 3.590

8.  Enhanced excitatory input to melanin concentrating hormone neurons during developmental period of high food intake is mediated by GABA.

Authors:  Ying Li; Anthony N van den Pol
Journal:  J Neurosci       Date:  2009-12-02       Impact factor: 6.167

Review 9.  Animals models of MCH function and what they can tell us about its role in energy balance.

Authors:  Pavlos Pissios
Journal:  Peptides       Date:  2009-05-15       Impact factor: 3.750

10.  A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor.

Authors:  Aram Elagoz; Duncan Henderson; Poda Suresh Babu; Sylvia Salter; Caroline Grahames; Lorna Bowers; Marie-Odile Roy; Patricia Laplante; Eric Grazzini; Sultan Ahmad; Paola M C Lembo
Journal:  Br J Pharmacol       Date:  2003-12-08       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.