| Literature DB >> 10559866 |
R Hoessel1, S Leclerc, J A Endicott, M E Nobel, A Lawrie, P Tunnah, M Leost, E Damiens, D Marie, D Marko, E Niederberger, W Tang, G Eisenbrand, L Meijer.
Abstract
Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. Here we identify indirubin and its analogues as potent inhibitors of cyclin-dependent kinases (CDKs). The crystal structure of CDK2 in complex with indirubin derivatives shows that indirubin interacts with the kinase's ATP-binding site through van der Waals interactions and three hydrogen bonds. Indirubin-3'-monoxime inhibits the proliferation of a large range of cells, mainly through arresting the cells in the G2/M phase of the cell cycle. These results have implications for therapeutic optimization of indigoids.Entities:
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Year: 1999 PMID： 10559866 DOI： 10.1038/9035
Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824