X Guangda1, X Bangshun, L Xiujian, H Yangzhong. 1. Department of Endocrinology, Guangzhou Army Wuhan General Hospital of PLA, Wuluo Road 299, Wuhan, PR China.
Abstract
OBJECTIVE: To examine whether the Apovarepsilon(4) allele is associated with an increased risk for exercise-induced silent myocardial ischemia (SI) in non-insulin-dependent diabetes mellitus (NIDDM). METHODS:One-hundred and sixty-six NIDDM patients with normal rest electrocardiography were selected randomly. Of them, 77 cases were SI, and 89 without SI. Seventy-two healthy individuals without SI were also selected as controls. Polymerase chain reaction/ASO probes was used to determined their mouthwash DNA apolipoprotein E genotypes. RESULTS: (1) In the NIDDM with SI group, the prevalence of epsilon(4)/(3) was 31.2%, which was significantly higher than 9.7% in control and 7.9% in NIDDM without SI (P<0.005). epsilon(3)/(3) was 55.8%, which was significantly lower than 73.6% in control and NIDDM without SI (P<0.05). (2) In the NIDDM without SI group, epsilon(4)/(3) was 7.9%, which was significantly lower than 18.7% in NIDDM (P<0.05). In addition, the epsilon(4) allele prevalence was 19.5%, which was significantly higher than 5.6% in NIDDM without SI (P<0.005), and 9% in control, 12% in NIDDM (P<0.05). (3) In the epsilon(4)/(3)epsilon(4)/(4) group for NIDDM, the prevalence of SI was 77%, which was significantly higher than 39% in the epsilon(3)/(3) group and 29% in the epsilon(2)/(2)epsilon(3)/(2) group (P<0.005). CONCLUSION: The epsilon(4) allele increases the risk for SI in NIDDM.
RCT Entities:
OBJECTIVE: To examine whether the Apovarepsilon(4) allele is associated with an increased risk for exercise-induced silent myocardial ischemia (SI) in non-insulin-dependent diabetes mellitus (NIDDM). METHODS: One-hundred and sixty-six NIDDM patients with normal rest electrocardiography were selected randomly. Of them, 77 cases were SI, and 89 without SI. Seventy-two healthy individuals without SI were also selected as controls. Polymerase chain reaction/ASO probes was used to determined their mouthwash DNA apolipoprotein E genotypes. RESULTS: (1) In the NIDDM with SI group, the prevalence of epsilon(4)/(3) was 31.2%, which was significantly higher than 9.7% in control and 7.9% in NIDDM without SI (P<0.005). epsilon(3)/(3) was 55.8%, which was significantly lower than 73.6% in control and NIDDM without SI (P<0.05). (2) In the NIDDM without SI group, epsilon(4)/(3) was 7.9%, which was significantly lower than 18.7% in NIDDM (P<0.05). In addition, the epsilon(4) allele prevalence was 19.5%, which was significantly higher than 5.6% in NIDDM without SI (P<0.005), and 9% in control, 12% in NIDDM (P<0.05). (3) In the epsilon(4)/(3)epsilon(4)/(4) group for NIDDM, the prevalence of SI was 77%, which was significantly higher than 39% in the epsilon(3)/(3) group and 29% in the epsilon(2)/(2)epsilon(3)/(2) group (P<0.005). CONCLUSION: The epsilon(4) allele increases the risk for SI in NIDDM.
Authors: Iciar Martín-Timón; Cristina Sevillano-Collantes; Amparo Segura-Galindo; Francisco Javier Del Cañizo-Gómez Journal: World J Diabetes Date: 2014-08-15