Literature DB >> 10559374

Dependence of echovirus 9 on the enterovirus RNA replication inhibitor 2-(alpha-Hydroxybenzyl)-benzimidazole maps to nonstructural protein 2C.

D Hadaschik1, M Klein, H Zimmermann, H J Eggers, B Nelsen-Salz.   

Abstract

HBB [2-(alpha-hydroxybenzyl)-benzimidazole] selectively inhibits RNA synthesis of most enteroviruses. However, isolation of HBB-dependent variants is possible. Sequence analysis and characterization of recombinant viruses revealed that HBB dependence maps to the nonstructural protein 2C. A single point mutation at position C(4782)U is sufficient to establish the HBB-dependent phenotype in our echovirus 9 model.

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Year:  1999        PMID： 10559374      PMCID： PMC113111     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  20 in total

1.  Poliovirus 2C region functions during encapsidation of viral RNA.

Authors:  L M Vance; N Moscufo; M Chow; B A Heinz
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

2.  Cell attachment and mouse virulence of echovirus 9 correlate with an RGD motif in the capsid protein VP1.

Authors:  H Zimmermann; H J Eggers; B Nelsen-Salz
Journal:  Virology       Date:  1997-06-23       Impact factor: 3.616

3.  A new superfamily of putative NTP-binding domains encoded by genomes of small DNA and RNA viruses.

Authors:  A E Gorbalenya; E V Koonin; Y I Wolf
Journal:  FEBS Lett       Date:  1990-03-12       Impact factor: 4.124

4.  Isolation of poliovirus 2C mutants defective in viral RNA synthesis.

Authors:  J P Li; D Baltimore
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

5.  Molecular cloning and sequence determination of the complete genome of the virulent echovirus 9 strain barty.

Authors:  H Zimmermann; H J Eggers; B Nelsen-Salz
Journal:  Virus Genes       Date:  1996       Impact factor: 2.332

6.  Production of guanidine-resistant and -dependent poliovirus mutants from cloned cDNA: mutations in polypeptide 2C are directly responsible for altered guanidine sensitivity.

Authors:  S E Pincus; E Wimmer
Journal:  J Virol       Date:  1986-11       Impact factor: 5.103

7.  Guanidine-resistant mutants of poliovirus have distinct mutations in peptide 2C.

Authors:  R F Baltera; D R Tershak
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

8.  Genetic analysis of an NTP-binding motif in poliovirus polypeptide 2C.

Authors:  C Mirzayan; E Wimmer
Journal:  Virology       Date:  1992-08       Impact factor: 3.616

9.  Antiviral effect of guanidine.

Authors:  W A RIGHTSEL; J R DICE; R J McALPINE; E A TIMM; I W McLEAN; G J DIXON; F M SCHABEL
Journal:  Science       Date:  1961-08-25       Impact factor: 47.728

10.  Spectrum and characteristics of the virus inhibitory action of 2-(alpha-hydroxybenzyl)-benzimidazole.

Authors:  H J EGGERS; I TAMM
Journal:  J Exp Med       Date:  1961-04-01       Impact factor: 14.307
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  7 in total

1.  Mutations in the 2C region of poliovirus responsible for altered sensitivity to benzimidazole derivatives.

Authors:  H Shimizu; M Agoh; Y Agoh; H Yoshida; K Yoshii; T Yoneyama; A Hagiwara; T Miyamura
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

2.  Biochemical and structural characterization of hepatitis A virus 2C reveals an unusual ribonuclease activity on single-stranded RNA.

Authors:  Pu Chen; Justyna Aleksandra Wojdyla; Ombretta Colasanti; Zhijian Li; Bo Qin; Meitian Wang; Volker Lohmann; Sheng Cui
Journal:  Nucleic Acids Res       Date:  2022-08-10       Impact factor: 19.160

3.  The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

Authors:  Armando M De Palma; Ward Heggermont; Kjerstin Lanke; Bruno Coutard; Mirko Bergmann; Anna-Maria Monforte; Bruno Canard; Erik De Clercq; Alba Chimirri; Gerhard Pürstinger; Jacques Rohayem; Frank van Kuppeveld; Johan Neyts
Journal:  J Virol       Date:  2008-03-12       Impact factor: 5.103

4.  Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner.

Authors:  Lisa Bauer; Roberto Manganaro; Birgit Zonsics; Jeroen R P M Strating; Priscila El Kazzi; Moira Lorenzo Lopez; Rachel Ulferts; Clara van Hoey; Maria J Maté; Thierry Langer; Bruno Coutard; Andrea Brancale; Frank J M van Kuppeveld
Journal:  ACS Infect Dis       Date:  2019-07-31       Impact factor: 5.084

5.  Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.

Authors:  Daniel L Hurdiss; Priscila El Kazzi; Lisa Bauer; Nicolas Papageorgiou; François P Ferron; Tim Donselaar; Arno L W van Vliet; Tatiana M Shamorkina; Joost Snijder; Bruno Canard; Etienne Decroly; Andrea Brancale; Tzviya Zeev-Ben-Mordehai; Friedrich Förster; Frank J M van Kuppeveld; Bruno Coutard
Journal:  Sci Adv       Date:  2022-01-05       Impact factor: 14.136

6.  Potential use of antiviral agents in polio eradication.

Authors:  Armando M De Palma; Gerhard Pürstinger; Eva Wimmer; Amy K Patick; Koen Andries; Bart Rombaut; Erik De Clercq; Johan Neyts
Journal:  Emerg Infect Dis       Date:  2008-04       Impact factor: 6.883

Review 7.  Replication and Inhibitors of Enteroviruses and Parechoviruses.

Authors:  Lonneke van der Linden; Katja C Wolthers; Frank J M van Kuppeveld
Journal:  Viruses       Date:  2015-08-10       Impact factor: 5.048
  7 in total

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