Literature DB >> 10559370

Quantitation of latent varicella-zoster virus and herpes simplex virus genomes in human trigeminal ganglia.

S R Pevenstein1, R K Williams, D McChesney, E K Mont, J E Smialek, S E Straus.   

Abstract

Using real-time fluorescence PCR, we quantitated the numbers of copies of latent varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) genomes in 15 human trigeminal ganglia. Eight (53%) and 1 (7%) of 15 ganglia were PCR positive for HSV-1 or -2 glycoprotein G genes, with means of 2,902 +/- 1,082 (standard error of the mean) or 109 genomes/10(5) cells, respectively. Eleven of 14 (79%) to 13 of 15 (87%) of the ganglia were PCR positive for VZV gene 29, 31, or 62. Pooling of the results for the three VZV genes yielded a mean of 258 +/- 38 genomes/10(5) ganglion cells. These levels of latent viral genome loads have implications for virus distribution in and reactivation from human sensory ganglia.

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Year:  1999        PMID： 10559370      PMCID： PMC113107     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  34 in total

1.  Latent herpes simplex virus in human trigeminal ganglia. Detection of an immediate early gene "anti-sense" transcript by in situ hybridization.

Authors:  K D Croen; J M Ostrove; L J Dragovic; J E Smialek; S E Straus
Journal:  N Engl J Med       Date:  1987-12-03       Impact factor: 91.245

2.  RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons.

Authors:  J G Stevens; E K Wagner; G B Devi-Rao; M L Cook; L T Feldman
Journal:  Science       Date:  1987-02-27       Impact factor: 47.728

3.  Homology between Epstein-Barr virus DNA and viral DNA from Burkitt's lymphoma and nasopharyngeal carcinoma determined by DNA-DNA reassociation kinetics.

Authors:  M Nonoyama; J S Pagano
Journal:  Nature       Date:  1973-03-02       Impact factor: 49.962

4.  Recurrences after oral and genital herpes simplex virus infection. Influence of site of infection and viral type.

Authors:  W E Lafferty; R W Coombs; J Benedetti; C Critchlow; L Corey
Journal:  N Engl J Med       Date:  1987-06-04       Impact factor: 91.245

5.  RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice.

Authors:  A M Deatly; J G Spivack; E Lavi; N W Fraser
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

6.  Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans.

Authors:  S Efstathiou; A C Minson; H J Field; J R Anderson; P Wildy
Journal:  J Virol       Date:  1986-02       Impact factor: 5.103

7.  Detection of herpes simplex virus mRNA in latently infected trigeminal ganglion neurons by in situ hybridization.

Authors:  R B Tenser; M Dawson; S J Ressel; M E Dunstan
Journal:  Ann Neurol       Date:  1982-03       Impact factor: 10.422

8.  Recombinant varicella-zoster virus glycoproteins E and I: immunologic responses and clearance of virus in a guinea pig model of chronic uveitis.

Authors:  H Kimura; Y Wang; L Pesnicak; J I Cohen; J J Hooks; S E Straus; R K Williams
Journal:  J Infect Dis       Date:  1998-08       Impact factor: 5.226

9.  Varicella-zoster virus DNA in human sensory ganglia.

Authors:  D H Gilden; A Vafai; Y Shtram; Y Becker; M Devlin; M Wellish
Journal:  Nature       Date:  1983 Dec 1-7       Impact factor: 49.962

10.  Neuronal and lymphocytic populations in human trigeminal ganglia: implications for ageing and for latent virus.

Authors:  M J Ball; K Nuttall; K G Warren
Journal:  Neuropathol Appl Neurobiol       Date:  1982 May-Jun       Impact factor: 8.090
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  75 in total

1.  Rapid detection of enterovirus RNA in cerebrospinal fluid specimens with a novel single-tube real-time reverse transcription-PCR assay.

Authors:  W A Verstrepen; S Kuhn; M M Kockx; M E Van De Vyvere; A H Mertens
Journal:  J Clin Microbiol       Date:  2001-11       Impact factor: 5.948

Review 2.  Real-time PCR in virology.

Authors:  Ian M Mackay; Katherine E Arden; Andreas Nitsche
Journal:  Nucleic Acids Res       Date:  2002-03-15       Impact factor: 16.971

3.  Lack of association between HSV-1 DNA in the brain, Alzheimer's disease and apolipoprotein E4.

Authors:  A R Marques; S E Straus; G Fahle; S Weir; G Csako; S H Fischer
Journal:  J Neurovirol       Date:  2001-02       Impact factor: 2.643

4.  Differential cytokine responses following Marek's disease virus infection of chickens differing in resistance to Marek's disease.

Authors:  Pete Kaiser; Greg Underwood; Fred Davison
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

5.  Comparison of quantitations of viral load in varicella and zoster.

Authors:  H Kimura; S Kido; T Ozaki; N Tanaka; Y Ito; R K Williams; T Morishima
Journal:  J Clin Microbiol       Date:  2000-06       Impact factor: 5.948

6.  Analysis of individual human trigeminal ganglia for latent herpes simplex virus type 1 and varicella-zoster virus nucleic acids using real-time PCR.

Authors:  R J Cohrs; J Randall; J Smith; D H Gilden; C Dabrowski; H van Der Keyl; R Tal-Singer
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

7.  Fatal varicella zoster virus infection as first manifestation of idiopathic CD4+ T-cell lymphocytopenia.

Authors:  K Hochauf; D Bandt; C Pöhlmann; S Monecke; M Toma; S Trautmann
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2005-10       Impact factor: 3.267

8.  Varicella-Zoster Virus (VZV) Small Noncoding RNAs Antisense to the VZV Latency-Encoded Transcript VLT Enhance Viral Replication.

Authors:  Punam Bisht; Biswajit Das; Paul R Kinchington; Ronald S Goldstein
Journal:  J Virol       Date:  2020-06-16       Impact factor: 5.103

9.  A locus on mouse chromosome 6 that determines resistance to herpes simplex virus also influences reactivation, while an unlinked locus augments resistance of female mice.

Authors:  Patric Lundberg; Paula Welander; Harry Openshaw; Christina Nalbandian; Carl Edwards; Lyle Moldawer; Edouard Cantin
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

10.  Varicella-zoster virus infection of human neural cells in vivo.

Authors:  Armin Baiker; Klaus Fabel; Antonio Cozzio; Leigh Zerboni; Konstanze Fabel; Marvin Sommer; Nobuko Uchida; Dongping He; Irving Weissman; Ann M Arvin
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-09       Impact factor: 11.205
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