Literature DB >> 10559280

Integration of hepadnavirus DNA in infected liver: evidence for a linear precursor.

W Yang1, J Summers.   

Abstract

DNA of the avian hepadnavirus, duck hepatitis B virus, was found to be integrated at low abundance into the cellular DNA extracted from the livers of infected ducklings. The frequency of integration was estimated to be at least one viral genome per 10(3) to 10(4) cells by 6 days postinfection. The structures of virus-cell junctions determined by sequencing were compared with those of virus-virus junctions formed by nonhomologous recombination between the ends of linear viral DNA forms. This comparison allowed us to conclude that linear viral DNA was the preferential form used as an integration substrate. Potential factors promoting viral DNA integration during chronic infection are discussed.

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Year:  1999        PMID： 10559280      PMCID： PMC113017     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

Review 1.  Hepatitis B viruses and hepatocellular carcinoma.

Authors:  M A Buendia
Journal:  Adv Cancer Res       Date:  1992       Impact factor: 6.242

2.  Covalently closed circular viral DNA formed from two types of linear DNA in woodchuck hepatitis virus-infected liver.

Authors:  W Yang; W S Mason; J Summers
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

3.  Illegitimate replication of linear hepadnavirus DNA through nonhomologous recombination.

Authors:  W Yang; J Summers
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

4.  Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus.

Authors:  R J Lenhoff; J Summers
Journal:  J Virol       Date:  1994-07       Impact factor: 5.103

5.  Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes.

Authors:  R J Lenhoff; J Summers
Journal:  J Virol       Date:  1994-09       Impact factor: 5.103

Review 6.  Hepatitis B virus replication--an update.

Authors:  M Nassal; H Schaller
Journal:  J Viral Hepat       Date:  1996-09       Impact factor: 3.728

7.  Loss and acquisition of duck hepatitis B virus integrations in lineages of LMH-D2 chicken hepatoma cells.

Authors:  S S Gong; A D Jensen; C E Rogler
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

8.  Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses.

Authors:  L J Hansen; B C Tennant; C Seeger; D Ganem
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272

Review 9.  Hepatitis B virus immunopathology.

Authors:  F V Chisari; C Ferrari
Journal:  Springer Semin Immunopathol       Date:  1995

10.  Duck hepatitis B virus integrations in LMH chicken hepatoma cells: identification and characterization of new episomally derived integrations.

Authors:  S S Gong; A D Jensen; H Wang; C E Rogler
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103
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  49 in total

1.  Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy.

Authors:  L Luckenbaugh; K M Kitrinos; W E Delaney; J Hu
Journal:  J Viral Hepat       Date:  2014-11-14       Impact factor: 3.728

2.  Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration.

Authors:  Colin A Bill; Jesse Summers
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-16       Impact factor: 11.205

3.  Identification of an Intermediate in Hepatitis B Virus Covalently Closed Circular (CCC) DNA Formation and Sensitive and Selective CCC DNA Detection.

Authors:  Jun Luo; Xiuji Cui; Lu Gao; Jianming Hu
Journal:  J Virol       Date:  2017-08-10       Impact factor: 5.103

Review 4.  Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics.

Authors:  Ju-Tao Guo; Haitao Guo
Journal:  Antiviral Res       Date:  2015-08-10       Impact factor: 5.970

Review 5.  Animal models and the molecular biology of hepadnavirus infection.

Authors:  William S Mason
Journal:  Cold Spring Harb Perspect Med       Date:  2015-04-01       Impact factor: 6.915

6.  Effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA in HBeAg-positive chronic hepatitis B patients.

Authors:  Hai-Ying Lu; Li-Wei Zhuang; Yan-Yan Yu; Chong-Wen Si; Jun Li; Jian-Jun Zhang; Zheng Zeng; Xin-Yue Chen; Zhong-Hou Han; Yong Chen
Journal:  World J Gastroenterol       Date:  2008-02-28       Impact factor: 5.742

Review 7.  Molecular biology of hepatitis B virus infection.

Authors:  Christoph Seeger; William S Mason
Journal:  Virology       Date:  2015-03-07       Impact factor: 3.616

Review 8.  Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B.

Authors:  Bidisha Mitra; Roshan J Thapa; Haitao Guo; Timothy M Block
Journal:  Antiviral Res       Date:  2018-08-24       Impact factor: 5.970

9.  The amount of hepatocyte turnover that occurred during resolution of transient hepadnavirus infections was lower when virus replication was inhibited with entecavir.

Authors:  William S Mason; Chunxiao Xu; Huey Chi Low; Jeffry Saputelli; Carol E Aldrich; Catherine Scougall; Arend Grosse; Richard Colonno; Sam Litwin; Allison R Jilbert
Journal:  J Virol       Date:  2008-12-10       Impact factor: 5.103

10.  Genomic fossils calibrate the long-term evolution of hepadnaviruses.

Authors:  Clément Gilbert; Cédric Feschotte
Journal:  PLoS Biol       Date:  2010-09-28       Impact factor: 8.029
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