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Literature DB >> 26272257

Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics.

Abstract

Persistent hepatitis B virus (HBV) infection relies on the stable maintenance and proper functioning of a nuclear episomal form of the viral genome called covalently closed circular (ccc) DNA. One of the major reasons for the failure of currently available antiviral therapeutics to achieve a cure of chronic HBV infection is their inability to eradicate or inactivate cccDNA. In this review article, we summarize our current understanding of cccDNA metabolism in hepatocytes and the modulation of cccDNA by host pathophysiological and immunological cues. Perspectives on the future investigation of cccDNA biology, as well as strategies and progress in therapeutic elimination and/or transcriptional silencing of cccDNA through rational design and phenotypic screenings, are also discussed. This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B."

Entities: CellLine Chemical Disease Gene Species

Keywords: Antiviral; DNA repair; Hepatitis B virus; Innate immunity; cccDNA

Mesh：

Substances：

Year: 2015 PMID： 26272257 PMCID： PMC4586118 DOI： 10.1016/j.antiviral.2015.08.005

Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970

139 in total

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54 in total

1. Activation of Stimulator of Interferon Genes in Hepatocytes Suppresses the Replication of Hepatitis B Virus.

Authors: Fang Guo; Liudi Tang; Sainan Shu; Mohit Sehgal; Muhammad Sheraz; Bowei Liu; Qiong Zhao; Junjun Cheng; Xuesen Zhao; Tianlun Zhou; Jinhong Chang; Ju-Tao Guo
Journal: Antimicrob Agents Chemother Date: 2017-09-22 Impact factor: 5.191

2. Hepatitis B virus X protein crosses out Smc5/6 complex to maintain covalently closed circular DNA transcription.

Authors: Bidisha Mitra; Haitao Guo
Journal: Hepatology Date: 2016-10-28 Impact factor: 17.425

Review 3. Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B.

Authors: Bidisha Mitra; Roshan J Thapa; Haitao Guo; Timothy M Block
Journal: Antiviral Res Date: 2018-08-24 Impact factor: 5.970

4. An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases.

Authors: Zahra Zahid Piracha; Umar Saeed; Jumi Kim; Hyeonjoong Kwon; Yong-Joon Chwae; Hyun Woong Lee; Jin Hong Lim; Sun Park; Ho-Joon Shin; Kyongmin Kim
Journal: J Virol Date: 2020-07-30 Impact factor: 5.103

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Authors: Balasubramanian Venkatakrishnan; Adam Zlotnick
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Authors: Pinghu Zhang; Fei Liu; Fang Guo; Qiong Zhao; Jinhong Chang; Ju-Tao Guo
Journal: Antiviral Res Date: 2016-04-12 Impact factor: 5.970