Literature DB >> 10555149

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs.

T C He1, T A Chan, B Vogelstein, K W Kinzler.   

Abstract

PPARB was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC) cells. PPARdelta expression was elevated in CRCs and repressed by APC in CRC cells. This repression was mediated by beta-catenin/Tcf-4-responsive elements in the PPARdelta promotor. The ability of PPARs to bind eicosanoids suggested that PPARdelta might be a target of chemopreventive non-steroidal anti-inflammatory drugs (NSAIDs). Reporters containing PPARdelta-responsive elements were repressed by the NSAID sulindac. Furthermore, sulindac was able to disrupt the ability of PPARdelta to bind its recognition sequences. These findings suggest that NSAIDs inhibit tumorigenesis through inhibition of PPARdelta, the gene for which is normally regulated by APC.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10555149      PMCID： PMC3779681          DOI： 10.1016/s0092-8674(00)81664-5

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  61 in total

1.  Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway.

Authors:  R Hanif; A Pittas; Y Feng; M I Koutsos; L Qiao; L Staiano-Coico; S I Shiff; B Rigas
Journal:  Biochem Pharmacol       Date:  1996-07-26       Impact factor: 5.858

Review 2.  Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology.

Authors:  T Lemberger; B Desvergne; W Wahli
Journal:  Annu Rev Cell Dev Biol       Date:  1996       Impact factor: 13.827

3.  Loss-of-function mutations in PPAR gamma associated with human colon cancer.

Authors:  P Sarraf; E Mueller; W M Smith; H M Wright; J B Kum; L A Aaltonen; A de la Chapelle; B M Spiegelman; C Eng
Journal:  Mol Cell       Date:  1999-06       Impact factor: 17.970

Review 4.  Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?

Authors:  P Kastner; M Mark; P Chambon
Journal:  Cell       Date:  1995-12-15       Impact factor: 41.582

5.  Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.

Authors:  H Lim; R A Gupta; W G Ma; B C Paria; D E Moller; J D Morrow; R N DuBois; J M Trzaskos; S K Dey
Journal:  Genes Dev       Date:  1999-06-15       Impact factor: 11.361

6.  Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process.

Authors:  B S Reddy; T Kawamori; R A Lubet; V E Steele; G J Kelloff; C V Rao
Journal:  Cancer Res       Date:  1999-07-15       Impact factor: 12.701

7.  Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

Authors:  H Sano; Y Kawahito; R L Wilder; A Hashiramoto; S Mukai; K Asai; S Kimura; H Kato; M Kondo; T Hla
Journal:  Cancer Res       Date:  1995-09-01       Impact factor: 12.701

8.  Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2.

Authors:  M Tsujii; R N DuBois
Journal:  Cell       Date:  1995-11-03       Impact factor: 41.582

Review 9.  The nuclear receptor superfamily: the second decade.

Authors:  D J Mangelsdorf; C Thummel; M Beato; P Herrlich; G Schütz; K Umesono; B Blumberg; P Kastner; M Mark; P Chambon; R M Evans
Journal:  Cell       Date:  1995-12-15       Impact factor: 41.582

10.  Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts.

Authors:  X Zhang; S G Morham; R Langenbach; D A Young
Journal:  J Exp Med       Date:  1999-08-16       Impact factor: 14.307
View more
  288 in total

1.  Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.

Authors:  S Hino; S Kishida; T Michiue; A Fukui; I Sakamoto; S Takada; M Asashima; A Kikuchi
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

Review 2.  Anti-inflammatories for cardiovascular disease.

Authors:  J L Masferrer; P Needleman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

3.  Critical roles of PPAR beta/delta in keratinocyte response to inflammation.

Authors:  N S Tan; L Michalik; N Noy; R Yasmin; C Pacot; M Heim; B Flühmann; B Desvergne; W Wahli
Journal:  Genes Dev       Date:  2001-12-15       Impact factor: 11.361

4.  National Cancer Institute workshop on chemopreventive properties of nonsteroidal anti-inflammatory drugs: role of COX-dependent and -independent mechanisms.

Authors:  Daniel H Hwang; Victor Fung; Andrew J Dannenberg
Journal:  Neoplasia       Date:  2002 Mar-Apr       Impact factor: 5.715

5.  gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.

Authors:  F T Kolligs; B Kolligs; K M Hajra; G Hu; M Tani; K R Cho; E R Fearon
Journal:  Genes Dev       Date:  2000-06-01       Impact factor: 11.361

6.  Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice.

Authors:  E D Reis; M Roque; H Dansky; J T Fallon; J J Badimon; C Cordon-Cardo; S J Shiff; E A Fisher
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

7.  Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators.

Authors:  K Kim; K M Pang; M Evans; E D Hay
Journal:  Mol Biol Cell       Date:  2000-10       Impact factor: 4.138

Review 8.  Aspirin and colorectal cancer: back to the future.

Authors:  David Tougeron; Dan Sha; Sashidhar Manthravadi; Frank A Sinicrope
Journal:  Clin Cancer Res       Date:  2013-12-10       Impact factor: 12.531

9.  Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells.

Authors:  Michael G Borland; Ellen M Kehres; Christina Lee; Ashley L Wagner; Brooke E Shannon; Prajakta P Albrecht; Bokai Zhu; Frank J Gonzalez; Jeffrey M Peters
Journal:  Toxicology       Date:  2018-05-03       Impact factor: 4.221

10.  CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells.

Authors:  Weike Si; Quan Kang; Hue H Luu; Jong Kyung Park; Qing Luo; Wen-Xin Song; Wei Jiang; Xiaoji Luo; Xinmin Li; Hong Yin; Anthony G Montag; Rex C Haydon; Tong-Chuan He
Journal:  Mol Cell Biol       Date:  2006-04       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.