Literature DB >> 22467178

P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation.

Gary A Weisman1, Jean M Camden, Troy S Peterson, Deepa Ajit, Lucas T Woods, Laurie Erb.   

Abstract

Extracellular nucleotides induce cellular responses in the central nervous system (CNS) through the activation of ionotropic P2X and metabotropic P2Y nucleotide receptors. Activation of these receptors regulates a wide range of physiological and pathological processes. In this review, we present an overview of the current literature regarding P2X and P2Y receptors in the CNS with a focus on the contribution of P2X7 and P2Y(2) receptor-mediated responses to neuroinflammatory and neuroprotective mechanisms.

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Year:  2012        PMID： 22467178      PMCID： PMC3439567          DOI： 10.1007/s12035-012-8263-z

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  283 in total

1.  Heterogeneity of P2X receptors in sympathetic neurons: contribution of neuronal P2X1 receptors revealed using knockout mice.

Authors:  Jennifer A Calvert; Richard J Evans
Journal:  Mol Pharmacol       Date:  2004-01       Impact factor: 4.436

2.  Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy.

Authors:  Grant R J Gordon; Dinara V Baimoukhametova; Sarah A Hewitt; W R A Kosala J S Rajapaksha; Thomas E Fisher; Jaideep S Bains
Journal:  Nat Neurosci       Date:  2005-07-03       Impact factor: 24.884

3.  Interaction between P2X and nicotinic acetylcholine receptors in glutamate nerve terminals of the rat hippocampus.

Authors:  Ricardo J Rodrigues; Teresa Almeida; Alexandre de Mendonça; Rodrigo A Cunha
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

4.  Nucleotides released from Aβ₁₋₄₂ -treated microglial cells increase cell migration and Aβ₁₋₄₂ uptake through P2Y₂ receptor activation.

Authors:  Hye Jung Kim; Deepa Ajit; Troy S Peterson; Yanfang Wang; Jean M Camden; W Gibson Wood; Grace Y Sun; Laurie Erb; Michael Petris; Gary A Weisman
Journal:  J Neurochem       Date:  2012-03-14       Impact factor: 5.372

Review 5.  NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

Authors:  Jurg Tschopp; Kate Schroder
Journal:  Nat Rev Immunol       Date:  2010-02-19       Impact factor: 53.106

6.  Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation.

Authors:  S P Soltoff
Journal:  J Biol Chem       Date:  1998-09-04       Impact factor: 5.157

7.  P2X3 is expressed by DRG neurons that terminate in inner lamina II.

Authors:  L Vulchanova; M S Riedl; S J Shuster; L S Stone; K M Hargreaves; G Buell; A Surprenant; R A North; R Elde
Journal:  Eur J Neurosci       Date:  1998-11       Impact factor: 3.386

8.  The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12.

Authors:  Zhongji Liao; Cheikh I Seye; Gary A Weisman; Laurie Erb
Journal:  J Cell Sci       Date:  2007-05-01       Impact factor: 5.285

9.  P2Y receptors activate neuroprotective mechanisms in astrocytic cells.

Authors:  Nataliya E Chorna; Laura I Santiago-Pérez; Laurie Erb; Cheikh I Seye; Joseph T Neary; Grace Y Sun; Gary A Weisman; Fernando A González
Journal:  J Neurochem       Date:  2004-10       Impact factor: 5.372

10.  Activation of P2X(7) receptors stimulates the expression of P2Y(2) receptor mRNA in astrocytes cultured from rat brain.

Authors:  I D'Alimonte; R Ciccarelli; P Di Iorio; E Nargi; S Buccella; P Giuliani; M P Rathbone; S Jiang; F Caciagli; P Ballerini
Journal:  Int J Immunopathol Pharmacol       Date:  2007 Apr-Jun       Impact factor: 3.219
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  27 in total

Review 1.  P2X ion channel receptors and inflammation.

Authors:  Geoffrey Burnstock
Journal:  Purinergic Signal       Date:  2016-01-06       Impact factor: 3.765

2.  Quantifying Ca2+ current and permeability in ATP-gated P2X7 receptors.

Authors:  Xin Liang; Damien S K Samways; Kyle Wolf; Elizabeth A Bowles; Jennifer P Richards; Jonathan Bruno; Sébastien Dutertre; Richard J DiPaolo; Terrance M Egan
Journal:  J Biol Chem       Date:  2015-02-02       Impact factor: 5.157

Review 3.  P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.

Authors:  Gary A Weisman; Lucas T Woods; Laurie Erb; Cheikh I Seye
Journal:  CNS Neurol Disord Drug Targets       Date:  2012-09       Impact factor: 4.388

Review 4.  Purinergic receptors as potential therapeutic targets in Alzheimer's disease.

Authors:  Lucas T Woods; Deepa Ajit; Jean M Camden; Laurie Erb; Gary A Weisman
Journal:  Neuropharmacology       Date:  2015-10-28       Impact factor: 5.250

5.  Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.

Authors:  Savina Apolloni; Paola Fabbrizio; Chiara Parisi; Susanna Amadio; Cinzia Volonté
Journal:  Mol Neurobiol       Date:  2014-12-09       Impact factor: 5.590

6.  Loss of P2Y₂ nucleotide receptors enhances early pathology in the TgCRND8 mouse model of Alzheimer's disease.

Authors:  Deepa Ajit; Lucas T Woods; Jean M Camden; Christina N Thebeau; Farid G El-Sayed; Glen W Greeson; Laurie Erb; Michael J Petris; Douglas C Miller; Grace Y Sun; Gary A Weisman
Journal:  Mol Neurobiol       Date:  2013-11-06       Impact factor: 5.590

7.  Adenosine triphosphate released from HIV-infected macrophages regulates glutamatergic tone and dendritic spine density on neurons.

Authors:  Luis B Tovar-Y-Romo; Dennis L Kolson; Veera Venkata Ratnam Bandaru; Julia L Drewes; David R Graham; Norman J Haughey
Journal:  J Neuroimmune Pharmacol       Date:  2013-05-18       Impact factor: 4.147

Review 8.  P2Y receptors in Alzheimer's disease.

Authors:  Laurie Erb; Chen Cao; Deepa Ajit; Gary A Weisman
Journal:  Biol Cell       Date:  2014-10-13       Impact factor: 4.458

9.  Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells.

Authors:  Namyr A Martinez; Alondra M Ayala; Magdiel Martinez; Freddyson J Martinez-Rivera; Jorge D Miranda; Walter I Silva
Journal:  J Biol Chem       Date:  2016-04-18       Impact factor: 5.157

10.  Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor.

Authors:  Sonia Guha; Gabriel C Baltazar; Erin E Coffey; Leigh-Anne Tu; Jason C Lim; Jonathan M Beckel; Shaun Patel; Thor Eysteinsson; Wennan Lu; Ann O'Brien-Jenkins; Alan M Laties; Claire H Mitchell
Journal:  FASEB J       Date:  2013-08-20       Impact factor: 5.191
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