| Literature DB >> 10549448 |
C K Mauck1, M M Callahan, J Baker, K Arbogast, R Veazey, R Stock, Z Pan, C S Morrison, M Chen-Mok, D F Archer, H L Gabelnick.
Abstract
Two studies in rhesus monkeys have shown that progesterone implants, Depo-Provera and Norplant, were associated with vaginal thinning. Progesterone implants have also been associated with an increased risk of simian immunodeficiency virus (SIV) acquisition. This study in 16 women was done to assess vaginal epithelial thickness and number of cell layers from biopsies taken in the untreated follicular and luteal phases, and at 1 month and 3 months after administration of Depo-Provera. There was no significant change over time in either parameter from biopsies obtained in the luteal phase compared with those at either time after Depo-Provera administration. There was also no change in the mean number of Langerhans cells in vaginal wall specimens and no change in cervical ectopy. It appears that women do not respond to exogenous progestins with the dramatic vaginal thinning seen in rhesus monkeys.Entities:
Keywords: Americas; Biology; Cervical Effects; Cervix; Contraception; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Depo-provera--side effects; Developed Countries; Diseases; Family Planning; Genitalia; Genitalia, Female; Medroxyprogesterone Acetate--side effects; North America; Northern America; Physiology; Research Report; United States; Urogenital System; Uterus; Vaginal Abnormalities; Virginia
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Year: 1999 PMID： 10549448 DOI： 10.1016/s0010-7824(99)00058-x
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375