Literature DB >> 10544240

A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates.

E P Bennett1, H Hassan, M A Hollingsworth, H Clausen.   

Abstract

A novel member of the human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase gene family, designated GalNAc-T7, was cloned and expressed. GalNAc-T7 exhibited different properties compared to other characterized members of this gene family, in showing apparent exclusive specificity for partially GalNAc-glycosylated acceptor substrates. GalNAc-T7 showed no activity with a large panel of non-glycosylated peptides, but was selectively activated by partial GalNAc glycosylation of peptide substrates derived from the tandem repeats of human MUC2 and rat submaxillary gland mucin. The function of GalNAc-T7 is suggested to be as a follow-up enzyme in the initiation step of O-glycosylation.

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Year:  1999        PMID： 10544240     DOI： 10.1016/s0014-5793(99)01268-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  37 in total

1.  Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis.

Authors:  Yun Kong; Hiren J Joshi; Katrine Ter-Borch Gram Schjoldager; Thomas Daugbjerg Madsen; Thomas A Gerken; Malene B Vester-Christensen; Hans H Wandall; Eric Paul Bennett; Steven B Levery; Sergey Y Vakhrushev; Henrik Clausen
Journal:  Glycobiology       Date:  2014-08-25       Impact factor: 4.313

2.  De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.

Authors:  Kirstine Lavrsen; Sally Dabelsteen; Sergey Y Vakhrushev; Asha M R Levann; Amalie Dahl Haue; August Dylander; Ulla Mandel; Lars Hansen; Morten Frödin; Eric P Bennett; Hans H Wandall
Journal:  J Biol Chem       Date:  2017-11-29       Impact factor: 5.157

3.  Glycopeptide N-acetylgalactosaminyltransferase specificities for O-glycosylated sites on MUC5AC mucin motif peptides.

Authors:  D Tetaert; K G Ten Hagen; C Richet; A Boersma; J Gagnon; P Degand
Journal:  Biochem J       Date:  2001-07-01       Impact factor: 3.857

4.  Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx.

Authors:  Leonhard Möckl; Kayvon Pedram; Anish R Roy; Venkatesh Krishnan; Anna-Karin Gustavsson; Oliver Dorigo; Carolyn R Bertozzi; W E Moerner
Journal:  Dev Cell       Date:  2019-05-16       Impact factor: 12.270

5.  The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection.

Authors:  Jayalakshmi Raman; Timothy A Fritz; Thomas A Gerken; Oliver Jamison; David Live; Mian Liu; Lawrence A Tabak
Journal:  J Biol Chem       Date:  2008-06-18       Impact factor: 5.157

6.  Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma.

Authors:  Joana Gomes; Nuno T Marcos; Nora Berois; Eduardo Osinaga; Ana Magalhães; João Pinto-de-Sousa; Raquel Almeida; Fátima Gärtner; Celso A Reis
Journal:  J Histochem Cytochem       Date:  2008-10-14       Impact factor: 2.479

7.  Mucin-type O-glycosylation is controlled by short- and long-range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase family.

Authors:  Leslie Revoredo; Shengjun Wang; Eric Paul Bennett; Henrik Clausen; Kelley W Moremen; Donald L Jarvis; Kelly G Ten Hagen; Lawrence A Tabak; Thomas A Gerken
Journal:  Glycobiology       Date:  2015-11-26       Impact factor: 4.313

8.  N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistry.

Authors:  Chen Wu; Xiaodan Guo; Weina Wang; Yun Wang; Yaojun Shan; Bo Zhang; Wenqian Song; Sisi Ma; Jianfeng Ge; Hao Deng; Mingsheng Zhu
Journal:  BMC Cancer       Date:  2010-04-01       Impact factor: 4.430

9.  p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene.

Authors:  Hiroto Izumi; Ryo Ohta; Gunji Nagatani; Tomoko Ise; Yoshifumi Nakayama; Minoru Nomoto; Kimitoshi Kohno
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

Review 10.  Recent insights into the biological roles of mucin-type O-glycosylation.

Authors:  E Tian; Kelly G Ten Hagen
Journal:  Glycoconj J       Date:  2008-08-10       Impact factor: 2.916
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