Restoration of contractile function in the enlarged left ventricle by exclusion of remodeled akinetic anterior segment: surgical strategy, myocardial protection, and angiographic results.

A variant of the Dor cardioprotective approach for reducing ventricular volume was applied to 12 consecutive postinfarction patients with akinetic anterior segments. Cardioplegia was avoided for restoration, but used for revascularization and valve replacement. The continually perfused beating open heart was used for protection during surgical anterior ventricular restoration (SAVR). These ischemic cardiomyopathy patients (age 77 +/- 6 years) preoperatively had high LVEDVI (170 vs 75 mL/m2, normal) and LVESVI (132 vs 25 mL/m2, normal) and 20 +/- 8% ejection fraction (mean +/- S.D.). An oval patch with outer flange for hemostasis was used. Patients also underwent revascularization (10/12), reoperation (6/12), and valve procedures (6/12). Continuous perfusion of the beating open heart was used for cardiac protection during restoration. Blood cardioplegia was used for revascularization and valvular procedures. Transesophageal echocardiogram (TEE) estimated intraventricular contractility in all patients, and biplane ventriculograms were used in 8 patients to measure cardioreduction. Immediate hemodynamic performance was excellent in all patients, despite 178 +/- 34 minutes of bypass. Extracorporeal circulation was stopped 10 minutes after closing the ventriculotomy. No intraaortic balloon pump or LV assist devices were needed. Ejection fraction estimated by TEE increased from 20% to 45%; and biplane ventriculograms showed 28% reduction of LVEDVI, 39% reduction of LVESVI, and raised ejection fraction from 20% to 35%. The spherical ventricular shape after akinetic infarction was made into a more normal elliptical contour by this procedure. Subsequently, restoration may become as important as revascularization in treating akinetic segments after anterior infarction.