| Literature DB >> 10529801 |
Abstract
Most imprinted loci have key regulatory elements that are methylated on only one of the parental chromosomes. For several of these 'differentially methylated regions', recent studies establish that the unmethylated chromosome has a specialized chromatin organization that is characterized by nuclease hypersensitivity. The novel data raise the question of whether specific proteins and associated chromatin features regulate the allele-specificity of DNA methylation at these imprinting control elements.Entities:
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Year: 1999 PMID： 10529801 DOI： 10.1016/s0168-9525(99)01822-3
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639