OBJECTIVE: Recently, it has been proposed that hereditary coagulation abnormalities leading to an increased venous thrombosis risk may play a role in the development of preeclampsia. We tested this hypothesis in women who have had preeclampsia compared with matched control subjects. STUDY DESIGN: We conducted a case-control study of 163 women with preeclampsia during 1991-1996. Control subjects were matched for age and delivery date. Patients and control subjects were tested for the presence of factor V Leiden, prothrombin 20210A allele, protein C, protein S, and antithrombin deficiency. Logistic regression methods were used for data analysis. RESULTS: The prevalence of these genetic risk factors was similar in the patient group (12.9%) and the control group (12.9%; odds ratio, 1.0; 95% confidence interval, 0.5-3.9). Unexpectedly, we found a high prevalence of factor V Leiden in the control group (9.2%). CONCLUSION: We found no differences in the prevalence of genetic risk factors of thrombosis in women with preeclampsia compared with control subjects.
OBJECTIVE: Recently, it has been proposed that hereditary coagulation abnormalities leading to an increased venous thrombosis risk may play a role in the development of preeclampsia. We tested this hypothesis in women who have had preeclampsia compared with matched control subjects. STUDY DESIGN: We conducted a case-control study of 163 women with preeclampsia during 1991-1996. Control subjects were matched for age and delivery date. Patients and control subjects were tested for the presence of factor V Leiden, prothrombin 20210A allele, protein C, protein S, and antithrombin deficiency. Logistic regression methods were used for data analysis. RESULTS: The prevalence of these genetic risk factors was similar in the patient group (12.9%) and the control group (12.9%; odds ratio, 1.0; 95% confidence interval, 0.5-3.9). Unexpectedly, we found a high prevalence of factor V Leiden in the control group (9.2%). CONCLUSION: We found no differences in the prevalence of genetic risk factors of thrombosis in women with preeclampsia compared with control subjects.
Authors: Gian Luca Salvagno; Giuseppe Lippi; Massimo Franchini; Giovanni Targher; Martina Montagnana; Massimo Franchi; Gian Cesare Guidi Journal: Blood Transfus Date: 2007-11 Impact factor: 3.443
Authors: Danyelle R A Rios; Patrícia Nessrala Alpoim; Lara Carvalho Godoi; Fernanda Santos Mendes; Bashir Lwaleed; Lirlândia P Sousa; Luiza O Perucci; Maria G Carvalho; Karina B G Borges; Luci M S Dusse Journal: J Thromb Thrombolysis Date: 2017-11 Impact factor: 2.300
Authors: Cynthia Villarreal; Gerardo García-Aguirre; Carmen Hernández; Olynka Vega; José R Borbolla; María T Collados Journal: J Thromb Thrombolysis Date: 2002-10 Impact factor: 2.300
Authors: Bas B van Rijn; Arie Franx; Eric A P Steegers; Christianne J M de Groot; Rogier M Bertina; Gerard Pasterkamp; Hieronymus A M Voorbij; Hein W Bruinse; Mark Roest Journal: PLoS One Date: 2008-04-02 Impact factor: 3.240