Literature DB >> 19165673

Genetic thrombophilia variants and risk for preeclampsia among American Indians.

Lyle G Best1, Sheri T Dorsam, Melanie Nadeau, Larry Burd, Cindy M Anderson.   

Abstract

OBJECTIVE: To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia.
METHODS: A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms.
RESULTS: The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found.
CONCLUSION: The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.

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Year:  2009        PMID： 19165673      PMCID： PMC6097878          DOI： 10.1080/10641950802419887

Source DB:  PubMed          Journal:  Hypertens Pregnancy        ISSN： 1064-1955            Impact factor:   2.108


  36 in total

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Authors:  F R Rosendaal; C J Doggen; A Zivelin; V R Arruda; M Aiach; D S Siscovick; A Hillarp; H H Watzke; F Bernardi; A M Cumming; F E Preston; P H Reitsma
Journal:  Thromb Haemost       Date:  1998-04       Impact factor: 5.249

5.  Incidence of Arg506 --> Gln mutation (factor V Leiden) in Pima Indians.

Authors:  H P Kohler; M Boothby; L McCormack; W C Knowler; P J Grant
Journal:  Thromb Haemost       Date:  1997-08       Impact factor: 5.249

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7.  World distribution of factor V Leiden.

Authors:  D C Rees; M Cox; J B Clegg
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8.  Mutation in blood coagulation factor V associated with resistance to activated protein C.

Authors:  R M Bertina; B P Koeleman; T Koster; F R Rosendaal; R J Dirven; H de Ronde; P A van der Velden; P H Reitsma
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9.  The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis.

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  6 in total

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2.  Thrombophilic mutations and susceptibility to preeclampsia in Western Iran.

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Journal:  J Thromb Thrombolysis       Date:  2012-01       Impact factor: 2.300

3.  Recruiting American Indian women for a genetic epidemiology study.

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Journal:  Public Health Genomics       Date:  2010-07-09       Impact factor: 2.000

4.  Pre-eclampsia in American Indians/Alaska Natives and Whites: The Significance of Body Mass Index.

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5.  Unactivated leukocyte expression of C-reactive protein is minimal and not dependent on rs1205 genotype.

Authors:  L G Best; C Azure; K Martell; K S Tsosie; B Voels
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6.  Association between thrombophilia gene polymorphisms and preeclampsia: a meta-analysis.

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  6 in total

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