| Literature DB >> 10519163 |
Z Dibbs1, K Kurrelmeyer, D Kalra, Y Seta, F Wang, B Bozkurt, G Baumgarten, N Sivasubramanian, D L Mann.
Abstract
Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro-inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.Entities:
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Year: 1999 PMID： 10519163 DOI： 10.1111/paa.1999.111.5.423
Source DB: PubMed Journal: Proc Assoc Am Physicians ISSN： 1081-650X