Literature DB >> 10517644

Whither goest the RGS proteins?

D P Siderovski1, B Strockbine, C I Behe.   

Abstract

Studies of the desensitization of G protein-coupled signal transduction have led to the discovery of a family of guanosine triphosphatase-activating proteins (GAPs) for heterotrimeric G protein alpha subunits - the "regulator of G protein signaling" or RGS proteins. In considering both documented and potential functions of several RGS protein family members with demonstrable multidomain compositions (p115RhoGEF, PDZRhoGEF, Axin, Axil/Conductin, D-AKAP2, the G protein-coupled receptor kinases [GRKs], the DEP/GGL/RGS subfamily [RGS6, RGS7, RGS9, RGS11], and RGS12), this review explores the shift in our appreciation of the RGS proteins from unidimensional desensitizing agents to multifocal signal transduction regulators.

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Year:  1999        PMID： 10517644     DOI： 10.1080/10409239991209273

Source DB:  PubMed          Journal:  Crit Rev Biochem Mol Biol        ISSN： 1040-9238            Impact factor:   8.250


  20 in total

Review 1.  Clinical spectrum and pathogenesis of pseudohypoparathyroidism.

Authors:  M A Levine
Journal:  Rev Endocr Metab Disord       Date:  2000-11       Impact factor: 6.514

2.  Regulation of T cell activation, anxiety, and male aggression by RGS2.

Authors:  A J Oliveira-Dos-Santos; G Matsumoto; B E Snow; D Bai; F P Houston; I Q Whishaw; S Mariathasan; T Sasaki; A Wakeham; P S Ohashi; J C Roder; C A Barnes; D P Siderovski; J M Penninger
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

3.  Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.

Authors:  Xinyan Huang; Ying Fu; Raelene A Charbeneau; Thomas L Saunders; Douglas K Taylor; Kurt D Hankenson; Mark W Russell; Louis G D'Alecy; Richard R Neubig
Journal:  Mol Cell Biol       Date:  2006-09       Impact factor: 4.272

4.  Active Galpha(q) subunits and M3 acetylcholine receptors promote distinct modes of association of RGS2 with the plasma membrane.

Authors:  Michael A Clark; Pooja R Sethi; Nevin A Lambert
Journal:  FEBS Lett       Date:  2007-01-26       Impact factor: 4.124

Review 5.  State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics.

Authors:  Christopher A Johnston; Francis S Willard; J Kevin Ramer; Rainer Blaesius; C Natalia Roques; David P Siderovski
Journal:  Comb Chem High Throughput Screen       Date:  2008-06       Impact factor: 1.339

6.  Regulator of G-protein signaling 5 enhances portal vein invasion in hepatocellular carcinoma.

Authors:  Yumi Umeno; Sachiko Ogasawara; Jun Akiba; Satoshi Hattori; Hironori Kusano; Osamu Nakashima; Hironori Koga; Takuji Torimura; Ryoji Yamakawa; Hirohisa Yano
Journal:  Oncol Lett       Date:  2017-11-23       Impact factor: 2.967

Review 7.  The role of G protein-coupled receptor kinases in the pathology of malignant tumors.

Authors:  Wu-Yi Sun; Jing-Jing Wu; Wen-Ting Peng; Jia-Chang Sun; Wei Wei
Journal:  Acta Pharmacol Sin       Date:  2018-06-19       Impact factor: 6.150

8.  Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments.

Authors:  G Hu; G F Jang; C W Cowan; T G Wensel; K Palczewski
Journal:  J Biol Chem       Date:  2001-04-05       Impact factor: 5.157

9.  The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.

Authors:  Simone L Sandiford; Vladlen Z Slepak
Journal:  Biochemistry       Date:  2009-03-17       Impact factor: 3.162

10.  Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling.

Authors:  Lucimar T Ferreira; Lianne B Dale; Fabiola M Ribeiro; Andy V Babwah; Macarena Pampillo; Stephen S G Ferguson
Journal:  J Biol Chem       Date:  2009-08-28       Impact factor: 5.157
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