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Literature DB >> 10516070

Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection.

T Nishizawa¹, H Okamoto, F Tsuda, T Aikawa, Y Sugai, K Konishi, Y Akahane, M Ukita, T Tanaka, Y Miyakawa, M Mayumi.

Abstract

Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.

Entities: Disease Species

Mesh：

Substances：
DNA, Viral

Year: 1999 PMID： 10516070 PMCID： PMC112996

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

26 in total

1. Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations.

Authors: A Meyerhans; R Cheynier; J Albert; M Seth; S Kwok; J Sninsky; L Morfeldt-Månson; B Asjö; S Wain-Hobson
Journal: Cell Date: 1989-09-08 Impact factor: 41.582

2. Determination of antibodies to TT virus (TTV) and application to blood donors and patients with post-transfusion non-A to G hepatitis in Japan.

Authors: F Tsuda; H Okamoto; M Ukita; T Tanaka; Y Akahane; K Konishi; H Yoshizawa; Y Miyakawa; M Mayumi
Journal: J Virol Methods Date: 1999-02 Impact factor: 2.014

3. Replication of the genome of a hepatitis B--like virus by reverse transcription of an RNA intermediate.

Authors: J Summers; W S Mason
Journal: Cell Date: 1982-06 Impact factor: 41.582

4. Marked genomic heterogeneity and frequent mixed infection of TT virus demonstrated by PCR with primers from coding and noncoding regions.

Authors: H Okamoto; M Takahashi; T Nishizawa; M Ukita; M Fukuda; F Tsuda; Y Miyakawa; M Mayumi
Journal: Virology Date: 1999-07-05 Impact factor: 3.616

5. The entire nucleotide sequence of a TT virus isolate from the United States (TUS01): comparison with reported isolates and phylogenetic analysis.

Authors: H Okamoto; T Nishizawa; M Ukita; M Takahashi; M Fukuda; H Iizuka; Y Miyakawa; M Mayumi
Journal: Virology Date: 1999-07-05 Impact factor: 3.616

6. Identification of a novel GC-rich 113-nucleotide region to complete the circular, single-stranded DNA genome of TT virus, the first human circovirus.

Authors: H Miyata; H Tsunoda; A Kazi; A Yamada; M A Khan; J Murakami; T Kamahora; K Shiraki; S Hino
Journal: J Virol Date: 1999-05 Impact factor: 5.103

7. Molecular and biophysical characterization of TT virus: evidence for a new virus family infecting humans.

Authors: I K Mushahwar; J C Erker; A S Muerhoff; T P Leary; J N Simons; L G Birkenmeyer; M L Chalmers; T J Pilot-Matias; S M Dexai
Journal: Proc Natl Acad Sci U S A Date: 1999-03-16 Impact factor: 11.205

8. High prevalence of TT virus infection in Brazilian blood donors.

Authors: C Niel; J M de Oliveira; R S Ross; S A Gomes; M Roggendorf; S Viazov
Journal: J Med Virol Date: 1999-03 Impact factor: 2.327

9. New genotypes of TT virus (TTV) and a genotyping assay based on restriction fragment length polymorphism.

Authors: Y Tanaka; M Mizokami; E Orito; T Ohno; T Nakano; T Kato; H Kato; M Mukaide; Y M Park; B S Kim; R Ueda
Journal: FEBS Lett Date: 1998-10-23 Impact factor: 4.124

10. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins.

Authors: A J Weiner; M J Brauer; J Rosenblatt; K H Richman; J Tung; K Crawford; F Bonino; G Saracco; Q L Choo; M Houghton
Journal: Virology Date: 1991-02 Impact factor: 3.616

13 in total

1. Extensive homologous recombination among widely divergent TT viruses.

Authors: M Worobey
Journal: J Virol Date: 2000-08 Impact factor: 5.103

2. Isolation of multiple TT virus genotypes from spleen biopsy tissue from a Hodgkin's disease patient: genome reorganization and diversity in the hypervariable region.

Authors: Ilijas Jelcic; Agnes Hotz-Wagenblatt; Andreas Hunziker; Harald Zur Hausen; Ethel-Michele de Villiers
Journal: J Virol Date: 2004-07 Impact factor: 5.103

3. Dynamics of persistent TT virus infection, as determined in patients treated with alpha interferon for concomitant hepatitis C virus infection.

Authors: F Maggi; M Pistello; M Vatteroni; S Presciuttini; S Marchi; P Isola; C Fornai; S Fagnani; E Andreoli; G Antonelli; M Bendinelli
Journal: J Virol Date: 2001-12 Impact factor: 5.103

Review 4. Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans.

Authors: M Bendinelli; M Pistello; F Maggi; C Fornai; G Freer; M L Vatteroni
Journal: Clin Microbiol Rev Date: 2001-01 Impact factor: 26.132