Literature DB >> 10508371

DNA Responds to Ionizing Radiation as an Insulator, Not as a "Molecular Wire"

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Abstract

The yields of radicals trapped on DNA, measured by EPR spectroscopy of oligodeoxyribonucleotide crystals (the EPR spectrum of a single crystal of d(CCCTAGGG) is shown), are found to be very high (0.7 µmol J(-1)) and insensitive to long-range (>10(6) base pairs) versus short-range stacking (8 base pairs) of the bases. These observations are evidence that DNA at 4 K has the properties of an insulator and argue against DNA acting as a "molecular wire".

Entities:  

Year:  1999        PMID： 10508371      PMCID： PMC2791346     

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  24 in total

1.  Nature of biological electron transfer.

Authors:  C C Moser; J M Keske; K Warncke; R S Farid; P L Dutton
Journal:  Nature       Date:  1992-02-27       Impact factor: 49.962

2.  Radiation-induced DNA damage as a function of hydration. I. Release of unaltered bases.

Authors:  S G Swarts; M D Sevilla; D Becker; C J Tokar; K T Wheeler
Journal:  Radiat Res       Date:  1992-03       Impact factor: 2.841

3.  On the Mechanism of Long-Range Electron Transfer through DNA.

Authors:  Bernd Giese; Stephan Wessely; Martin Spormann; Ute Lindemann; Eric Meggers; Maria E Michel-Beyerle
Journal:  Angew Chem Int Ed Engl       Date:  1999-04-01       Impact factor: 15.336

4.  Electron Tunneling in DNA.

Authors:  Anthony Harriman
Journal:  Angew Chem Int Ed Engl       Date:  1999-04-01       Impact factor: 15.336

5.  Radiolytic pathways in gamma-irradiated DNA: influence of chemical and conformational factors.

Authors:  S Gregoli; M Olast; A Bertinchamps
Journal:  Radiat Res       Date:  1982-02       Impact factor: 2.841

6.  Long-range photoinduced electron transfer through a DNA helix.

Authors:  C J Murphy; M R Arkin; Y Jenkins; N D Ghatlia; S H Bossmann; N J Turro; J K Barton
Journal:  Science       Date:  1993-11-12       Impact factor: 47.728

7.  Structure of d(CCCTAGGG): comparison with nine isomorphous octamer sequences reveals four distinct patterns of sequence-dependent intermolecular interactions.

Authors:  D B Tippin; M Sundaralingam
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1996-09-01

8.  Radiation chemical mechanisms of single- and double-strand break formation in irradiated SV40 DNA.

Authors:  R E Krisch; M B Flick; C N Trumbore
Journal:  Radiat Res       Date:  1991-05       Impact factor: 2.841

9.  Free radical yields in A:T polydeoxynucleotides, oligodeoxynucleotides, and monodeoxynucleotides at 4 K.

Authors:  R A Spalletta; W A Bernhard
Journal:  Radiat Res       Date:  1992-04       Impact factor: 2.841

10.  Electron paramagnetic resonance investigation of X-irradiated poly(U), poly(A) and poly(A):poly(U): influence of hydration, packing and conformation on radical yield at 4 K.

Authors:  N E Mroczka; W A Bernhard
Journal:  Radiat Res       Date:  1995-12       Impact factor: 2.841
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  11 in total

1.  Free radical yields in crystalline DNA X-irradiated at 4 K.

Authors:  M G Debije; W A Bernhard
Journal:  Radiat Res       Date:  1999-12       Impact factor: 2.841

2.  Electron paramagnetic resonance evidence for a C3' sugar radical in crystalline d(CTCTCGAGAG) X-irradiated at 4 K.

Authors:  M G Debije; W A Bernhard
Journal:  Radiat Res       Date:  2001-05       Impact factor: 2.841

3.  The yield of strand breaks resulting from direct-type effects in crystalline DNA X-irradiated at 4 K and room temperature.

Authors:  M G Debije; Y Razskazovskiy; W A Bernhard
Journal:  J Am Chem Soc       Date:  2001-03-28       Impact factor: 15.419

4.  Strand breaks produced in X-írradiated crystalline DNA: influence of base sequence.

Authors:  Yuriy Razskazovskiy; Michael G Debije; William A Bernhard
Journal:  Radiat Res       Date:  2003-05       Impact factor: 2.841

5.  On the efficiency of hole and electron transfer from the hydration layer to DNA: An EPR study of crystalline DNA X-irradiated at 4 K.

Authors:  M G Debije; M D Strickler; W A Bernhard
Journal:  Radiat Res       Date:  2000-08       Impact factor: 2.841

Review 6.  Proton-coupled electron transfer in DNA on formation of radiation-produced ion radicals.

Authors:  Anil Kumar; Michael D Sevilla
Journal:  Chem Rev       Date:  2010-05-05       Impact factor: 60.622

7.  What is the initial chemical precursor of DNA strand breaks generated by direct-type effects?

Authors:  Shubhadeep Purkayastha; William A Bernhard
Journal:  J Phys Chem B       Date:  2004-11-25       Impact factor: 2.991

8.  Unaltered free base release from d(CGCGCG)2 produced by the direct effect of ionizing radiation at 4 K and room temperature.

Authors:  Kiran K Sharma; Shubhadeep Purkayastha; William A Bernhard
Journal:  Radiat Res       Date:  2007-05       Impact factor: 2.841

9.  Direct radiation damage to crystalline DNA: what is the source of unaltered base release?

Authors:  Y Razskazovskiy; M G Debije; W A Bernhard
Journal:  Radiat Res       Date:  2000-04       Impact factor: 2.841

10.  Excess electron trapping in duplex DNA: long range transfer via stacked adenines.

Authors:  Paul J Black; William A Bernhard
Journal:  J Phys Chem B       Date:  2012-10-24       Impact factor: 2.991
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