Literature DB >> 10508348

Spontaneous Formation of the Bioactive Form of the Tuberculosis Drug Isoniazid.

.   

Abstract

It works even without the enzyme: The formation of the bioactive form 1 of isoniazid inside Mycobacterium tuberculosis does not depend on specific interactions within the active site of the inhibited enzyme, but rather relies on the fast addition of acyl radicals to electron-deficient heterocycles such as NAD(+).

Entities:  

Year:  1999        PMID： 10508348     DOI： 10.1002/(sici)1521-3773(19990903)38:17<2588::aid-anie2588>3.0.co;2-8

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  21 in total

1.  Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.

Authors:  Eduardo Henrique Silva Sousa; Luiz Augusto Basso; Diógenes S Santos; Izaura Cirino Nogueira Diógenes; Elisane Longhinotti; Luiz Gonzaga de França Lopes; Icaro de Sousa Moreira
Journal:  J Biol Inorg Chem       Date:  2011-09-28       Impact factor: 3.358

Review 2.  Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.

Authors:  Sumit Chakraborty; Kyu Y Rhee
Journal:  Cold Spring Harb Perspect Med       Date:  2015-04-15       Impact factor: 6.915

3.  Classic reaction kinetics can explain complex patterns of antibiotic action.

Authors:  Pia Abel Zur Wiesch; Sören Abel; Spyridon Gkotzis; Paolo Ocampo; Jan Engelstädter; Trevor Hinkley; Carsten Magnus; Matthew K Waldor; Klas Udekwu; Ted Cohen
Journal:  Sci Transl Med       Date:  2015-05-13       Impact factor: 17.956

4.  Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.

Authors:  Catherine Vilchèze; Anthony D Baughn; JoAnn Tufariello; Lawrence W Leung; Mack Kuo; Christopher F Basler; David Alland; James C Sacchettini; Joel S Freundlich; William R Jacobs
Journal:  Antimicrob Agents Chemother       Date:  2011-05-31       Impact factor: 5.191

5.  Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.

Authors:  Feng Wang; Paras Jain; Gulcin Gulten; Zhen Liu; Yicheng Feng; Krishna Ganesula; Alifiya S Motiwala; Thomas R Ioerger; David Alland; Catherine Vilchèze; William R Jacobs; James C Sacchettini
Journal:  Antimicrob Agents Chemother       Date:  2010-06-21       Impact factor: 5.191

Review 6.  The Isoniazid Paradigm of Killing, Resistance, and Persistence in Mycobacterium tuberculosis.

Authors:  Catherine Vilchèze; William R Jacobs
Journal:  J Mol Biol       Date:  2019-02-21       Impact factor: 5.469

7.  Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.

Authors:  Catherine Vilchèze; Torin R Weisbrod; Bing Chen; Laurent Kremer; Manzour H Hazbón; Feng Wang; David Alland; James C Sacchettini; William R Jacobs
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

8.  Precise null deletion mutations of the mycothiol synthesis genes reveal their role in isoniazid and ethionamide resistance in Mycobacterium smegmatis.

Authors:  Xia Xu; Catherine Vilchèze; Yossef Av-Gay; Anaximandro Gómez-Velasco; William R Jacobs
Journal:  Antimicrob Agents Chemother       Date:  2011-04-18       Impact factor: 5.191

9.  Synthesis and biological activity of alkynoic acids derivatives against mycobacteria.

Authors:  Catherine Vilchèze; Lawrence W Leung; Robert Bittman; William R Jacobs
Journal:  Chem Phys Lipids       Date:  2015-08-06       Impact factor: 3.329

10.  Spin trapping investigation of peroxide- and isoniazid-induced radicals in Mycobacterium tuberculosis catalase-peroxidase.

Authors:  Kalina Ranguelova; Javier Suarez; Richard S Magliozzo; Ronald P Mason
Journal:  Biochemistry       Date:  2008-10-02       Impact factor: 3.162
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.