| Literature DB >> 10505972 |
M Clerici1, M L Fusi, D Caputo, F R Guerini, D Trabattoni, A Salvaggio, C L Cazzullo, D Arienti, M L Villa, H B Urnovitz, P Ferrante.
Abstract
A possible role for human endogenous retroviruses (HERV) in the pathogenesis of MS was investigated by analyzing HERV peptides-stimulated proliferation and cytokine production in MS patients with acute (AMS) or stable (SMS) disease. HERV peptides specific-proliferation and type 1 cytokine production by peripheral blood mononuclear cells was observed in AMS but not in SMS individuals, in whom a type 2 cytokine profile dominates. HERV peptides-stimulated immune responses were modified by changes in disease expression; mediated by CD4+ T lymphocytes; and not related to HLA class II molecules. These data suggest the possibility of a pathogenic role for HERV and HERV-specific immune responses in MS.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10505972 DOI： 10.1016/s0165-5728(99)00123-x
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478