Literature DB >> 33467098

Endogenous Retroviruses in Nervous System Disorders.

Victoria Gröger1, Alexander Emmer2, Martin S Staege3, Holger Cynis1.   

Abstract

Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.

Entities:  

Keywords:  amyotrophic lateral sclerosis; human endogenous retrovirus; monoclonal antibodies; multiple sclerosis

Year:  2021        PMID： 33467098      PMCID： PMC7829834          DOI： 10.3390/ph14010070

Source DB:  PubMed          Journal:  Pharmaceuticals (Basel)        ISSN： 1424-8247


  207 in total

1.  Human endogenous retrovirus-K contributes to motor neuron disease.

Authors:  Wenxue Li; Myoung-Hwa Lee; Lisa Henderson; Richa Tyagi; Muzna Bachani; Joseph Steiner; Emilie Campanac; Dax A Hoffman; Gloria von Geldern; Kory Johnson; Dragan Maric; H Douglas Morris; Margaret Lentz; Katherine Pak; Andrew Mammen; Lyle Ostrow; Jeffrey Rothstein; Avindra Nath
Journal:  Sci Transl Med       Date:  2015-09-30       Impact factor: 17.956

Review 2.  Silencing of endogenous retroviruses by heterochromatin.

Authors:  Sophia Groh; Gunnar Schotta
Journal:  Cell Mol Life Sci       Date:  2017-02-03       Impact factor: 9.261

3.  Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.

Authors:  Tongguang Wang; Marie Medynets; Kory R Johnson; Tara T Doucet-O'Hare; Brianna DiSanza; Wenxue Li; Yadi Xu; Anna Bagnell; Richa Tyagi; Kevon Sampson; Nasir Malik; Joseph Steiner; Alina Hadegan; Jeffrey Kowalak; James O'Malley; Dragan Maric; Avindra Nath
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-15       Impact factor: 11.205

4.  Augmented type 1 cytokines and human endogenous retroviruses specific immune responses in patients with acute multiple sclerosis.

Authors:  D Trabattoni; P Ferrante; M L Fusi; M Saresella; D Caputo; H Urnovitz; C L Cazzullo; M Clerici
Journal:  J Neurovirol       Date:  2000-05       Impact factor: 2.643

5.  SINE-R.C2 (a Homo sapiens specific retroposon) is homologous to CDNA from postmortem brain in schizophrenia and to two loci in the Xq21.3/Yp block linked to handedness and psychosis.

Authors:  H S Kim; R V Wadekar; O Takenaka; C Winstanley; F Mitsunaga; T Kageyama; B H Hyun; T J Crow
Journal:  Am J Med Genet       Date:  1999-10-15

6.  Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation.

Authors:  David Kremer; Tanja Schichel; Moritz Förster; Nevena Tzekova; Corinne Bernard; Paul van der Valk; Jack van Horssen; Hans-Peter Hartung; Hervé Perron; Patrick Küry
Journal:  Ann Neurol       Date:  2013-09-16       Impact factor: 10.422

7.  A phase II baseline versus treatment study to determine the efficacy of raltegravir (Isentress) in preventing progression of relapsing remitting multiple sclerosis as determined by gadolinium-enhanced MRI: The INSPIRE study.

Authors:  Julian Gold; Monica Marta; Ute C Meier; Tove Christensen; David Miller; Daniel Altmann; David Holden; Lucia Bianchi; Rocco Adiutori; David MacManus; Tarek Yousry; Klaus Schmierer; Benjamin Turner; Gavin Giovannoni
Journal:  Mult Scler Relat Disord       Date:  2018-06-28       Impact factor: 4.339

8.  Safety and tolerability of Triumeq in amyotrophic lateral sclerosis: the Lighthouse trial.

Authors:  Julian Gold; Dominic B Rowe; Matthew C Kiernan; Steve Vucic; Susan Mathers; Ruben P A van Eijk; Avindra Nath; Marta Garcia Montojo; Gina Norato; Ulisses A Santamaria; Mary-Louise Rogers; Andrea Malaspina; Vittoria Lombardi; Puja R Mehta; Henk-Jan Westeneng; Leonard H van den Berg; Ammar Al-Chalabi
Journal:  Amyotroph Lateral Scler Frontotemporal Degener       Date:  2019-07-08       Impact factor: 3.528

9.  Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis.

Authors:  Jeremy A Garson; Louise Usher; Ammar Al-Chalabi; Jim Huggett; Edmund F Day; Adele L McCormick
Journal:  Acta Neuropathol Commun       Date:  2019-03-18       Impact factor: 7.801

10.  B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity.

Authors:  Tomasz Brudek; Tove Christensen; Lars Aagaard; Thor Petersen; Hans J Hansen; Anné Møller-Larsen
Journal:  Retrovirology       Date:  2009-11-16       Impact factor: 4.602
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  7 in total

Review 1.  The Role of Transposable Elements of the Human Genome in Neuronal Function and Pathology.

Authors:  Ekaterina Chesnokova; Alexander Beletskiy; Peter Kolosov
Journal:  Int J Mol Sci       Date:  2022-05-23       Impact factor: 6.208

2.  Comment on: Endogenous retroviruses expressed in human tumours cannot be used as targets for anti-tumour vaccines.

Authors:  Joachim Denner
Journal:  Transl Oncol       Date:  2021-05       Impact factor: 4.243

3.  Genomics-Guided Drawing of Molecular and Pathophysiological Components of Malignant Regulatory Signatures Reveals a Pivotal Role in Human Diseases of Stem Cell-Associated Retroviral Sequences and Functionally-Active hESC Enhancers.

Authors:  Gennadi V Glinsky
Journal:  Front Oncol       Date:  2021-03-31       Impact factor: 6.244

Review 4.  Human Endogenous Retroviruses as Gene Expression Regulators: Insights from Animal Models into Human Diseases.

Authors:  Serpen Durnaoglu; Sun-Kyung Lee; Joohong Ahnn
Journal:  Mol Cells       Date:  2021-12-31       Impact factor: 5.034

5.  Immunogenicity of the Envelope Surface Unit of Human Endogenous Retrovirus K18 in Mice.

Authors:  Victoria Ilse; Rebekka Scholz; Michael Wermann; Marcel Naumann; Martin S Staege; Steffen Roßner; Holger Cynis
Journal:  Int J Mol Sci       Date:  2022-07-28       Impact factor: 6.208

Review 6.  HSV-1 and Endogenous Retroviruses as Risk Factors in Demyelination.

Authors:  Raquel Bello-Morales; Sabina Andreu; Inés Ripa; José Antonio López-Guerrero
Journal:  Int J Mol Sci       Date:  2021-05-27       Impact factor: 5.923

Review 7.  Retrotransposons as a Source of DNA Damage in Neurodegeneration.

Authors:  Eugenie Peze-Heidsieck; Tom Bonnifet; Rania Znaidi; Camille Ravel-Godreuil; Olivia Massiani-Beaudoin; Rajiv L Joshi; Julia Fuchs
Journal:  Front Aging Neurosci       Date:  2022-01-04       Impact factor: 5.750
  7 in total

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