Literature DB >> 10498741

Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein.

M M Slupska1, W M Luther, J H Chiang, H Yang, J H Miller.   

Abstract

We have previously described the hMYH cDNA and genomic clones (M. M. Slupska et al., J. Bacteriol. 178:3885-3892, 1996). Here, we report that the enzyme expressed from an hMYH cDNA clone in Escherichia coli complements the mutator phenotype in a mutY mutant and can remove A from an A. 8-hydroxydeoxyguanine mismatch and to a lesser extent can remove A from an A. G mismatch in vitro.

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Year:  1999        PMID： 10498741      PMCID： PMC103656          DOI： 10.1128/JB.181.19.6210-6213.1999

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  23 in total

Review 1.  The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine).

Authors:  M L Michaels; J H Miller
Journal:  J Bacteriol       Date:  1992-10       Impact factor: 3.490

2.  A repair system for 8-oxo-7,8-dihydrodeoxyguanine.

Authors:  M L Michaels; J Tchou; A P Grollman; J H Miller
Journal:  Biochemistry       Date:  1992-11-17       Impact factor: 3.162

3.  Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs.

Authors:  K G Au; S Clark; J H Miller; P Modrich
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

4.  Two nicking enzyme systems specific for mismatch-containing DNA in nuclear extracts from human cells.

Authors:  Y C Yeh; D Y Chang; J Masin; A L Lu
Journal:  J Biol Chem       Date:  1991-04-05       Impact factor: 5.157

5.  MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily.

Authors:  Y Guan; R C Manuel; A S Arvai; S S Parikh; C D Mol; J H Miller; S Lloyd; J A Tainer
Journal:  Nat Struct Biol       Date:  1998-12

6.  MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III.

Authors:  M L Michaels; L Pham; Y Nghiem; C Cruz; J H Miller
Journal:  Nucleic Acids Res       Date:  1990-07-11       Impact factor: 16.971

7.  Escherichia coli MutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A.C and A.G mispairs.

Authors:  J J Tsai-Wu; H F Liu; A L Lu
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

8.  Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.

Authors:  M L Michaels; C Cruz; A P Grollman; J H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

9.  The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions.

Authors:  Y Nghiem; M Cabrera; C G Cupples; J H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

10.  Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.

Authors:  S Shibutani; M Takeshita; A P Grollman
Journal:  Nature       Date:  1991-01-31       Impact factor: 49.962
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  55 in total

1.  hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs.

Authors:  I Boldogh; D Milligan; M S Lee; H Bassett; R S Lloyd; A K McCullough
Journal:  Nucleic Acids Res       Date:  2001-07-01       Impact factor: 16.971

2.  Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS.

Authors:  Haibo Bai; A-Lien Lu
Journal:  J Bacteriol       Date:  2006-11-17       Impact factor: 3.490

Review 3.  DNA glycosylases search for and remove oxidized DNA bases.

Authors:  Susan S Wallace
Journal:  Environ Mol Mutagen       Date:  2013-10-07       Impact factor: 3.216

4.  Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1.

Authors:  Guoli Shi; Dau-Yin Chang; Chih-Chien Cheng; Xin Guan; Ceslovas Venclovas; A-Lien Lu
Journal:  Biochem J       Date:  2006-11-15       Impact factor: 3.857

5.  Mutator effects in Escherichia coli caused by the expression of specific foreign genes.

Authors:  Vanessa Gabrovsky; Mitsuko Lynn Yamamoto; Jeffrey H Miller
Journal:  J Bacteriol       Date:  2005-07       Impact factor: 3.490

6.  Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis.

Authors:  Kazuya Shinmura; Masanori Goto; Hong Tao; Shun Matsuura; Tomonari Matsuda; Haruhiko Sugimura
Journal:  World J Gastroenterol       Date:  2012-12-21       Impact factor: 5.742

7.  Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer.

Authors:  Sucharita Kundu; Megan K Brinkmeyer; Alison L Livingston; Sheila S David
Journal:  DNA Repair (Amst)       Date:  2009-12-03

8.  N-terminus of the rat adenine glycosylase MYH affects excision rates and processing of MYH-generated abasic sites.

Authors:  Huaxian Ma; Heung M Lee; Ella W Englander
Journal:  Nucleic Acids Res       Date:  2004-08-13       Impact factor: 16.971

9.  Base excision repair and the role of MUTYH.

Authors:  Carla Kairupan; Rodney J Scott
Journal:  Hered Cancer Clin Pract       Date:  2007-12-15       Impact factor: 2.857

10.  Transcriptional mutagenesis induced by 8-oxoguanine in mammalian cells.

Authors:  Damien Brégeon; Paul-Antoine Peignon; Alain Sarasin
Journal:  PLoS Genet       Date:  2009-07-24       Impact factor: 5.917
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