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Literature DB >> 10496947

Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumonia.

M C McElroy¹, H R Harty, G E Hosford, G M Boylan, J F Pittet, T J Foster.

Abstract

We have shown that injury to alveolar epithelial type I cells may account, in part, for damage to the air-blood barrier of the lung in a rat model of Staphylococcus aureus pneumonia. We have also shown that alpha-toxin is an important cause of damage to the air-blood barrier; however, our data suggest that the toxin is not acting directly on alveolar type I cells.

Entities: Chemical

Mesh：

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Year: 1999 PMID： 10496947 PMCID： PMC96922 DOI： 10.1128/IAI.67.10.5541-5544.1999

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

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