Literature DB >> 10496932

Tumor necrosis factor (TNF) and a TNF-mimetic peptide modulate the granulomatous response to Mycobacterium bovis BCG infection in vivo.

D R Roach1, H Briscoe, K Baumgart, D A Rathjen, W J Britton.   

Abstract

Tumor necrosis factor (TNF) is a critical mediator in the immune response to mycobacteria, particularly in the formation and maintenance of granulomas. Treatment of Mycobacterium bovis BCG-infected mice with TNF and a TNF-mimetic peptide (TNF(70-80)) altered the number and cellular composition of granulomas. This change was associated with a moderate decrease in the bacterial burden.

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Year:  1999        PMID: 10496932      PMCID: PMC96907          DOI: 10.1128/IAI.67.10.5473-5476.1999

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  20 in total

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9.  The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection.

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  9 in total

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4.  Evaluation of memory immune response to mycobacterium extract among household contact of tuberculosis cases.

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  9 in total

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