| Literature DB >> 10496932 |
D R Roach1, H Briscoe, K Baumgart, D A Rathjen, W J Britton.
Abstract
Tumor necrosis factor (TNF) is a critical mediator in the immune response to mycobacteria, particularly in the formation and maintenance of granulomas. Treatment of Mycobacterium bovis BCG-infected mice with TNF and a TNF-mimetic peptide (TNF(70-80)) altered the number and cellular composition of granulomas. This change was associated with a moderate decrease in the bacterial burden.Entities:
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Year: 1999 PMID: 10496932 PMCID: PMC96907 DOI: 10.1128/IAI.67.10.5473-5476.1999
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441