Literature DB >> 10496931

An OspC-specific monoclonal antibody passively protects mice from tick-transmitted infection by Borrelia burgdorferi B31.

M L Mbow1, R D Gilmore, R G Titus.   

Abstract

A murine monoclonal antibody directed against Borrelia burgdorferi B31 outer surface protein C (OspC) antigen was generated by a method whereby borreliae were inoculated into the mouse via the natural transmission mode of tick feeding. Passive immunization with this antibody resulted in protection of C3H/HeJ and outbred mice from a tick-transmitted challenge infection. Immunofluorescence staining of borrelia cells indicated surface exposure of the OspC epitope reactive with the monoclonal antibody.

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Year:  1999        PMID： 10496931      PMCID： PMC96906          DOI： 10.1128/IAI.67.10.5470-5472.1999

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  14 in total

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Authors:  T J Kurtti; U G Munderloh; C A Hughes; S M Engstrom; R C Johnson
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

2.  Resolution of experimental and tick-borne Borrelia burgdorferi infection in mice by passive, but not active immunization using recombinant OspC.

Authors:  W Zhong; L Gern; T Stehle; C Museteanu; M Kramer; R Wallich; M M Simon
Journal:  Eur J Immunol       Date:  1999-03       Impact factor: 5.532

3.  Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB.

Authors:  C A Hughes; S M Engstrom; L A Coleman; C B Kodner; R C Johnson
Journal:  Infect Immun       Date:  1993-12       Impact factor: 3.441

4.  Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC.

Authors:  R D Gilmore; K J Kappel; M C Dolan; T R Burkot; B J Johnson
Journal:  Infect Immun       Date:  1996-06       Impact factor: 3.441

5.  Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.

Authors:  E Fikrig; S R Telford; S W Barthold; F S Kantor; A Spielman; R A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

6.  Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen.

Authors:  W S Probert; R B LeFebvre
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

7.  Standard system for infecting ticks (Acari: Ixodidae) with the Lyme disease spirochete, Borrelia burgdorferi.

Authors:  J Piesman
Journal:  J Med Entomol       Date:  1993-01       Impact factor: 2.278

8.  Ear punch biopsy method for detection and isolation of Borrelia burgdorferi from rodents.

Authors:  R J Sinsky; J Piesman
Journal:  J Clin Microbiol       Date:  1989-08       Impact factor: 5.948

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Authors:  V Preac-Mursic; B Wilske; E Patsouris; S Jauris; G Will; E Soutschek; S Rainhardt; G Lehnert; U Klockmann; P Mehraein
Journal:  Infection       Date:  1992 Nov-Dec       Impact factor: 3.553

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Authors:  A M de Silva; S R Telford; L R Brunet; S W Barthold; E Fikrig
Journal:  J Exp Med       Date:  1996-01-01       Impact factor: 14.307
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  43 in total

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Authors:  Christopher G Earnhart; Richard T Marconi
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2.  Analysis of antibody response in humans to the type A OspC loop 5 domain and assessment of the potential utility of the loop 5 epitope in Lyme disease vaccine development.

Authors:  Eric L Buckles; Christopher G Earnhart; Richard T Marconi
Journal:  Clin Vaccine Immunol       Date:  2006-10

3.  Epitope mapping of Borrelia burgdorferi OspC protein in homodimeric fold.

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Journal:  Protein Sci       Date:  2017-02-11       Impact factor: 6.725

4.  Lyme borreliosis in rhesus macaques: effects of corticosteroids on spirochetal load and isotype switching of anti-borrelia burgdorferi antibody.

Authors:  A R Pachner; K Amemiya; M Bartlett; H Schaefer; K Reddy; W F Zhang
Journal:  Clin Diagn Lab Immunol       Date:  2001-03

5.  Evaluation of the Borrelia burgdorferi BBA64 protein as a protective immunogen in mice.

Authors:  Kevin S Brandt; Toni G Patton; Anna S Allard; Melissa J Caimano; Justin D Radolf; Robert D Gilmore
Journal:  Clin Vaccine Immunol       Date:  2014-02-05

6.  Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences.

Authors:  Qilong Xu; Kristy McShan; Fang Ting Liang
Journal:  Mol Microbiol       Date:  2008-04-28       Impact factor: 3.501

7.  Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses.

Authors:  Fang Ting Liang; Jun Yan; M Lamine Mbow; Steven L Sviat; Robert D Gilmore; Mark Mamula; Erol Fikrig
Journal:  Infect Immun       Date:  2004-10       Impact factor: 3.441

8.  Maternal Antibodies Provide Bank Voles with Strain-Specific Protection against Infection by the Lyme Disease Pathogen.

Authors:  Andrea Gomez-Chamorro; Vanina Heinrich; Anouk Sarr; Owen Roethlisberger; Dolores Genné; Cindy Bregnard; Maxime Jacquet; Maarten J Voordouw
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9.  Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals.

Authors:  Dorothee Grimm; Kit Tilly; Rebecca Byram; Philip E Stewart; Jonathan G Krum; Dawn M Bueschel; Tom G Schwan; Paul F Policastro; Abdallah F Elias; Patricia A Rosa
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-17       Impact factor: 11.205

10.  Simultaneous coexpression of Borrelia burgdorferi Erp proteins occurs through a specific, erp locus-directed regulatory mechanism.

Authors:  Nazira El-Hage; Brian Stevenson
Journal:  J Bacteriol       Date:  2002-08       Impact factor: 3.490
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