Literature DB >> 10496083

Novel polymorphism in the 5'-untranslated region of the interleukin-4 gene.

A Takabayashi1, K Ihara, Y Sasaki, K Kusuhara, S Nishima, T Hara.   

Abstract

We found a novel polymorphism C/T change at position -34 counting from the first ATG codon, of the interleukin-4 (IL-4) gene, located between the TATA box and the first ATG on exon 1. The allelic frequency of this C/T polymorphism in 64 independent Japanese samples was 0.37:0.63. In addition, PCR-restriction fragment length polymorphism analysis revealed that the -34T/T polymorphism was always associated with -590T/T, a known polymorphism that increases IL-4 transcriptional activity.

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Year:  1999        PMID： 10496083     DOI： 10.1007/s100380050176

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  8 in total

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Review 7.  Association Between IL-4 Polymorphisms and Risk of Liver Disease: An Updated Meta-Analysis.

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8.  Association Between Promoter Polymorphisms of IL-1B, IL-4 and IL-6 Genes and a Viral Load Infected Women with Human Papillomavirus.

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  8 in total

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