Literature DB >> 104885

Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon.

W Schmidt, E Jähnchen.   

Abstract

13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum protein-binding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.

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Year:  1978        PMID： 104885     DOI： 10.1007/bf01981447

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  High stereospecificity of the benzodiazepine binding site on human serum albumin. Studies with d- and l-oxazepam hemisuccinate.

Authors:  W E Müller; U Wollert
Journal:  Mol Pharmacol       Date:  1975-01       Impact factor: 4.436

2.  Studies on the optical enantiomorphs of warfarin in man.

Authors:  R A O'Reilly
Journal:  Clin Pharmacol Ther       Date:  1974-08       Impact factor: 6.875

3.  Binding of d- and 1-oxazepam hemisuccinate to bovine serum albumin.

Authors:  W E Müller; U Wollert
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1974-11

4.  Pharmacokinetics of the warfarin enantiomers in rats.

Authors:  A Yacobi; G Levy
Journal:  J Pharmacokinet Biopharm       Date:  1974-06

5.  The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats.

Authors:  A Breckenridge; M L Orme
Journal:  Life Sci II       Date:  1972-04-08

6.  Species differences in the albumin binding of 2,4,6-trinitrobenzaldehyde, chlorophenoxyacetic acids, 2-(4'-hydroxybenzeneazo)benzoic acid and some other acidic drugs--the unique behavior of rat plasma albumin.

Authors:  D T Witiak; M W Whitehouse
Journal:  Biochem Pharmacol       Date:  1969-05       Impact factor: 5.858

7.  Protein binding of warfarin enantiomers in serum of humans and rats.

Authors:  A Yacobi; G Levy
Journal:  J Pharmacokinet Biopharm       Date:  1977-04

8.  Optical studies on the mechanism of the interaction of the enantiomers of the antiocagulant drugs phenprocoumon and warfarin with human serum albumin.

Authors:  N A Brown; E Jähnchen; W E Müller; U Wollert
Journal:  Mol Pharmacol       Date:  1977-01       Impact factor: 4.436

9.  Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man.

Authors:  D S Hewick; J McEwen
Journal:  J Pharm Pharmacol       Date:  1973-06       Impact factor: 3.765

10.  Stereoselective drug distribution and anticoagulant potency of the enantiomers of phenprocoumon in rats.

Authors:  W Schmidt; E Jähnchen
Journal:  J Pharm Pharmacol       Date:  1977-05       Impact factor: 3.765
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  3 in total

Review 1.  Stereoselectivity in clinical pharmacokinetics and drug development.

Authors:  D B Campbell
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1990 Apr-Jun       Impact factor: 2.441

2.  Interaction of phenylbutazone with racemic phenprocoumon and its enantiomers in rats.

Authors:  W Schmidt; E Jähnchen
Journal:  J Pharmacokinet Biopharm       Date:  1979-12

3.  Simultaneous Quantification and Pharmacokinetic Characterization of Doxapram and 2-Ketodoxapram in Porcine Plasma and Brain Tissue.

Authors:  Manuel Kraft; Kathrin I Foerster; Felix Wiedmann; Max Sauter; Amelie Paasche; Pablo L Blochberger; Baran Yesilgöz; Yannick L'hoste; Norbert Frey; Walter E Haefeli; Jürgen Burhenne; Constanze Schmidt
Journal:  Pharmaceutics       Date:  2022-03-31       Impact factor: 6.321
  3 in total

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