Calcium sulfate- and calcium phosphate-based bone substitutes. Mimicry of the mineral phase of bone.

Calcium sulfate and calcium phosphate have provided the orthopedic surgeon a viable alternative to autogenous bone grafting as either an osteoconductive bone void filler or a bone graft extender. These materials mimic the mineral phase of bone and are resorbed at a rate similar to the rate of bone formation. Thus, they are able to provide some structural support and prevent ingrowth of fibrous tissue while facilitating creeping substitution by the host bone.