BACKGROUND AND PURPOSE: The prevalence of poststroke depression is known to be high, but the knowledge of its neuropsychological correlates is limited. This 12-month prospective study was designed to evaluate the natural history of poststroke depression and to study its neuropsychological, clinical, and functional associates. METHODS: We studied a series of 106 consecutive patients (46 women and 60 men, mean age 65.8 years) with acute first-ever ischemic stroke. The patients underwent a neurological, psychiatric, and neuropsychological examination at 3 and 12 months after the stroke. The psychiatric diagnosis of depression was based on DSM-III-R-criteria. RESULTS: Depression was diagnosed in 53% of the patients at 3 months and in 42% of the patients at 12 months after the stroke. The prevalence of major depression was 9% at 3 months and 16% at 12 months. There was an association between poststroke depression and cognitive impairment; the domains most likely to be defective in stroke-related depression were memory (P=0.022), nonverbal problem solving (P=0.039), and attention and psychomotor speed (P=0.020). The presence of dysphasia increased the risk of major depression. The depressive patients were more dependent in ADL and had more severe impairment and handicap than the nondepressive patients. CONCLUSIONS: More than half of the patients suffer from depression after stroke, and the frequency of major depression seems to increase during the first year. In addition to dysphasia, poststroke depression is correlated with other cognitive deficits. We emphasize the importance of psychiatric evaluation of stroke patients.
BACKGROUND AND PURPOSE: The prevalence of poststroke depression is known to be high, but the knowledge of its neuropsychological correlates is limited. This 12-month prospective study was designed to evaluate the natural history of poststroke depression and to study its neuropsychological, clinical, and functional associates. METHODS: We studied a series of 106 consecutive patients (46 women and 60 men, mean age 65.8 years) with acute first-ever ischemic stroke. The patients underwent a neurological, psychiatric, and neuropsychological examination at 3 and 12 months after the stroke. The psychiatric diagnosis of depression was based on DSM-III-R-criteria. RESULTS:Depression was diagnosed in 53% of the patients at 3 months and in 42% of the patients at 12 months after the stroke. The prevalence of major depression was 9% at 3 months and 16% at 12 months. There was an association between poststroke depression and cognitive impairment; the domains most likely to be defective in stroke-related depression were memory (P=0.022), nonverbal problem solving (P=0.039), and attention and psychomotor speed (P=0.020). The presence of dysphasia increased the risk of major depression. The depressivepatients were more dependent in ADL and had more severe impairment and handicap than the nondepressivepatients. CONCLUSIONS: More than half of the patients suffer from depression after stroke, and the frequency of major depression seems to increase during the first year. In addition to dysphasia, poststroke depression is correlated with other cognitive deficits. We emphasize the importance of psychiatric evaluation of strokepatients.
Authors: Linda S Williams; Susan Ofner; Zhangsheng Yu; Rebecca J Beyth; Laurie Plue; Teresa Damush Journal: J Gen Intern Med Date: 2011-08 Impact factor: 5.128
Authors: Gabrielle M Harris; Janice Collins-McNeil; Qing Yang; Vu Q C Nguyen; Mark A Hirsch; Charles F Rhoads; Tami Guerrier; J George Thomas; Terrence M Pugh; Deanna Hamm; Carol Pereira; Janet Prvu Bettger Journal: J Stroke Cerebrovasc Dis Date: 2016-10-06 Impact factor: 2.136
Authors: Joshua Z Willey; Norbelina Disla; Yeseon Park Moon; Myunghee C Paik; Ralph L Sacco; Bernadette Boden-Albala; Mitchell S V Elkind; Clinton B Wright Journal: Stroke Date: 2010-07-29 Impact factor: 7.914
Authors: Bowie Han; Evaren E Page; Lauren M Stewart; Cassandra C Deford; James G Scott; Lauren H Schwartz; Jedidiah J Perdue; Deirdra R Terrell; Sara K Vesely; James N George Journal: Am J Hematol Date: 2015-05-28 Impact factor: 10.047
Authors: Ari L Harris; Jessica Elder; Nicholas D Schiff; Jonathan D Victor; Andrew M Goldfine Journal: Transl Stroke Res Date: 2013-10-19 Impact factor: 6.829
Authors: Joseph Ogavu Gyagenda; Edward Ddumba; Raymond Odokonyero; Mark Kaddumukasa; Martha Sajatovic; Kathyleen Smyth; Elly Katabira Journal: Afr Health Sci Date: 2015-12 Impact factor: 0.927