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Literature DB >> 10470044

Why is Deinococcus radiodurans so resistant to ionizing radiation?

Abstract

When exponential-phase cultures of Deinococcus radiodurans are exposed to a 5000-Gray dose of gamma radiation, individual cells suffer massive DNA damage. Despite this insult to their genetic integrity, these cells survive without loss of viability or evidence of mutation, repairing the damage by as-yet-poorly-understood mechanisms.

Entities: Disease Species

Mesh：

Substances：
DNA, Bacterial

Year: 1999 PMID： 10470044 DOI： 10.1016/s0966-842x(99)01566-8

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

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Cited

71 in total

1. The RecA proteins of Deinococcus radiodurans and Escherichia coli promote DNA strand exchange via inverse pathways.

Authors: Jong-Il Kim; Michael M Cox
Journal: Proc Natl Acad Sci U S A Date: 2002-06-04 Impact factor: 11.205

2. Predicted highly expressed genes of diverse prokaryotic genomes.

Authors: S Karlin; J Mrázek
Journal: J Bacteriol Date: 2000-09 Impact factor: 3.490

3. Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death.

Authors: Igor Shuryak; David J Brenner
Journal: Radiat Res Date: 2012-06-04 Impact factor: 2.841

4. Description of gamma radiation-resistant Geodermatophilus dictyosporus sp. nov. to accommodate the not validly named Geodermatophilus obscurus subsp. dictyosporus (Luedemann, 1968).

Authors: Maria del Carmen Montero-Calasanz; Karima Hezbri; Markus Göker; Haïtham Sghaier; Manfred Rohde; Cathrin Spröer; Peter Schumann; Hans-Peter Klenk
Journal: Extremophiles Date: 2014-11-16 Impact factor: 2.395

Why is Deinococcus radiodurans so resistant to ionizing radiation?

1. The RecA proteins of Deinococcus radiodurans and Escherichia coli promote DNA strand exchange via inverse pathways.

2. Predicted highly expressed genes of diverse prokaryotic genomes.

3. Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death.

4. Description of gamma radiation-resistant Geodermatophilus dictyosporus sp. nov. to accommodate the not validly named Geodermatophilus obscurus subsp. dictyosporus (Luedemann, 1968).

5. Unusual water flux in the extracellular polysaccharide of the cyanobacterium Nostoc commune.

6. Complete resonance assignments for the nudix hydrolase DR2356 of Deinococcus radiodurans.

Review 7. DNA toroids: framework for DNA repair in Deinococcus radiodurans and in germinating bacterial spores.

8. Crystal structure and mutational study of RecOR provide insight into its mode of DNA binding.

9. Deinococcus radiodurans PprI switches on DNA damage response and cellular survival networks after radiation damage.

10. Microbial diversity of cryptoendolithic communities from the McMurdo Dry Valleys, Antarctica.