Literature DB >> 10468571

Compactness of the denatured state of a fast-folding protein measured by submillisecond small-angle x-ray scattering.

L Pollack1, M W Tate, N C Darnton, J B Knight, S M Gruner, W A Eaton, R H Austin.   

Abstract

Time-resolved small-angle x-ray scattering was used to measure the radius of gyration of cytochrome c after initiation of folding by a pH jump. Submillisecond time resolution was obtained with a microfabricated diffusional mixer and synchrotron radiation. The results show that the protein first collapses to compact denatured structures before folding very fast to the native state.

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Year:  1999        PMID： 10468571      PMCID： PMC17851          DOI： 10.1073/pnas.96.18.10115

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

Review 1.  Protein folding in the landscape perspective: chevron plots and non-Arrhenius kinetics.

Authors:  H S Chan; K A Dill
Journal:  Proteins       Date:  1998-01

2.  Evidence for barrier-limited protein folding kinetics on the microsecond time scale.

Authors:  M C Shastry; H Roder
Journal:  Nat Struct Biol       Date:  1998-05

3.  Submillisecond protein folding kinetics studied by ultrarapid mixing.

Authors:  C K Chan; Y Hu; S Takahashi; D L Rousseau; W A Eaton; J Hofrichter
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

4.  Participation of the protein ligands in the folding of cytochrome c.

Authors:  J Babul; E Stellwagen
Journal:  Biochemistry       Date:  1972-03-28       Impact factor: 3.162

5.  Small angle neutron and x-ray scattering studies of concentrated protein solutions. II. Cytochrome C.

Authors:  C F Wu; S H Chen
Journal:  Biopolymers       Date:  1988-07       Impact factor: 2.505

Review 6.  Structures of folding intermediates.

Authors:  O B Ptitsyn
Journal:  Curr Opin Struct Biol       Date:  1995-02       Impact factor: 6.809

7.  Ultrafast signals in protein folding and the polypeptide contracted state.

Authors:  T R Sosnick; M D Shtilerman; L Mayne; S W Englander
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

8.  Folding of cytochrome c initiated by submillisecond mixing.

Authors:  S Takahashi; S R Yeh; T K Das; C K Chan; D S Gottfried; D L Rousseau
Journal:  Nat Struct Biol       Date:  1997-01

9.  Amide protection in an early folding intermediate of cytochrome c.

Authors:  J M Sauder; H Roder
Journal:  Fold Des       Date:  1998

10.  Kinetic mechanism of cytochrome c folding: involvement of the heme and its ligands.

Authors:  G A Elöve; A K Bhuyan; H Roder
Journal:  Biochemistry       Date:  1994-06-07       Impact factor: 3.162
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  68 in total

1.  Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2.

Authors:  A A Deniz; T A Laurence; G S Beligere; M Dahan; A B Martin; D S Chemla; P E Dawson; P G Schultz; S Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

2.  A kinetically significant intermediate in the folding of barnase.

Authors:  A R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

3.  Structural characterization of the pH-denatured states of ferricytochrome-c by synchrotron small angle X-ray scattering.

Authors:  S Cinelli; F Spinozzi; R Itri; S Finet; F Carsughi; G Onori; P Mariani
Journal:  Biophys J       Date:  2001-12       Impact factor: 4.033

4.  Rapid compaction during RNA folding.

Authors:  Rick Russell; Ian S Millett; Mark W Tate; Lisa W Kwok; Bradley Nakatani; Sol M Gruner; Simon G J Mochrie; Vijay Pande; Sebastian Doniach; Daniel Herschlag; Lois Pollack
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-02       Impact factor: 11.205

5.  Viewing protein folding from many perspectives.

Authors:  Charles L Brooks
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-05       Impact factor: 11.205

6.  Lifetimes of intermediates in the beta -sheet to alpha -helix transition of beta -lactoglobulin by using a diffusional IR mixer.

Authors:  E Kauffmann; N C Darnton; R H Austin; C Batt; K Gerwert
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-22       Impact factor: 11.205

7.  NMR and SAXS characterization of the denatured state of the chemotactic protein CheY: implications for protein folding initiation.

Authors:  P Garcia; L Serrano; D Durand; M Rico; M Bruix
Journal:  Protein Sci       Date:  2001-06       Impact factor: 6.725

8.  Microfluidics without microfabrication.

Authors:  Barry R Lutz; Jian Chen; Daniel T Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-01       Impact factor: 11.205

9.  Selective excitation of native fluctuations during thermal unfolding simulations: horse heart cytochrome c as a case study.

Authors:  Danilo Roccatano; Isabella Daidone; Marc-Antoine Ceruso; Cecilia Bossa; Alfredo Di Nola
Journal:  Biophys J       Date:  2003-03       Impact factor: 4.033

10.  Laminar-flow fluid mixer for fast fluorescence kinetics studies.

Authors:  Suzette A Pabit; Stephen J Hagen
Journal:  Biophys J       Date:  2002-11       Impact factor: 4.033
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