| Literature DB >> 10465529 |
A D Khanolkar1, D Lu, P Fan, X Tian, A Makriyannis.
Abstract
Novel analogs of (-)-delta8-tetrahydrocannabinol (delta8-THC) in which the conformation of the side chain was restricted by incorporating the first one or two carbons into a six membered ring fused with the aromatic phenolic A ring were synthesized. The affinities of the novel ligands for CB1 and CB2 indicated that the "southbound" chain conformer retained the highest affinity for both receptors.Entities:
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Year: 1999 PMID： 10465529 DOI： 10.1016/s0960-894x(99)00355-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823