| Literature DB >> 10454017 |
Abstract
High amounts of nitric oxide and TNF-alpha generated by activated macrophages induce several pathophysiological conditions during acute and chronic inflammation. Identification of new pharmacological reagents that can prevent TNF-alpha and/or NO overproduction is of considerable medical interest. In this report we provide evidence that the overproduction of TNF-alpha and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10454017 DOI： 10.1016/s0192-0561(99)00024-7
Source DB: PubMed Journal: Int J Immunopharmacol ISSN： 0192-0561