Literature DB >> 10450950

Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping.

W J Brouillette1, V R Atigadda, M Luo, G M Air, Y S Babu, S Bantia.   

Abstract

A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3-guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors.

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Year:  1999        PMID： 10450950     DOI： 10.1016/s0960-894x(99)00318-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Discovery of Influenza A virus neuraminidase inhibitors using support vector machine and Naïve Bayesian models.

Authors:  Wenwen Lian; Jiansong Fang; Chao Li; Xiaocong Pang; Ai-Lin Liu; Guan-Hua Du
Journal:  Mol Divers       Date:  2015-12-21       Impact factor: 2.943

2.  Docking and 3D QSAR study of thiourea analogs as potent inhibitors of influenza virus neuraminidase.

Authors:  Jiaying Sun; Shaoxi Cai; Hu Mei; Jian Li; Ning Yan; Yuanqiang Wang
Journal:  J Mol Model       Date:  2010-03-07       Impact factor: 1.810

3.  Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity.

Authors:  Yanwu Li; Arundutt Silamkoti; Gundurao Kolavi; Liyuan Mou; Shelly Gulati; Gillian M Air; Wayne J Brouillette
Journal:  Bioorg Med Chem       Date:  2012-05-17       Impact factor: 3.641

4.  Ethyl 4-butyl-amino-3-nitro-benzoate.

Authors:  Shivanagere Nagojappa Narendra Babu; Aisyah Saad Abdul Rahim; Shafida Abd Hamid; Kasthuri Balasubramani; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-08-08

5.  Ethyl 4-(2-hydroxy-ethyl-amino)-3-nitro-benzoate.

Authors:  Aisyah Saad Abdul Rahim; Shafida Abd Hamid; Shivanagere Nagojappa Narendra Babu; Wan-Sin Loh; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-17

6.  Combining crystallographic information and an aspherical-atom data bank in the evaluation of the electrostatic interaction energy in an enzyme-substrate complex: influenza neuraminidase inhibition.

Authors:  Paulina M Dominiak; Anatoliy Volkov; Adam P Dominiak; Katarzyna N Jarzembska; Philip Coppens
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-04-18

7.  Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6.

Authors:  Lalitha Venkatramani; Eric S Johnson; Gundurao Kolavi; Gillian M Air; Wayne J Brouillette; Blaine H M Mooers
Journal:  BMC Struct Biol       Date:  2012-05-06

8.  4-tert-Butyl-amino-3-nitro-benzoic acid.

Authors:  Shivanagere Nagojappa Narendra Babu; Aisyah Saad Abdul Rahim; Shafida Abd Hamid; Samuel Robinson Jebas; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-05-07

Review 9.  Influenza is now a preventable disease.

Authors:  J S Oxford; R Lambkin
Journal:  Int J Antimicrob Agents       Date:  2006-03-27       Impact factor: 5.283
  9 in total

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