Literature DB >> 10450420

Genetic structure and dynamics of Plasmodium falciparum infections in the Kilombero region of Tanzania.

H A Babiker1, L C Ranford-Cartwright, D Walliker.   

Abstract

Plasmodium falciparum parasites exist as genetically distinct haploid clones in infected people. In the Kilombero valley in south-east Tanzania, at least 85% of the inhabitants of Michenga village harbour more than one clone. Using 2 highly polymorphic unlinked markers, it has been estimated that each infected person harbours between one and 6 P. falciparum clones at any one time, with a mean of 3.5 clones. When mosquitoes acquire gametocytes of 2 different clones in a blood meal, crossing generates recombinant clones differing from their parental genotypes. The inbreeding coefficient of the parasite population has been estimated as 0.33.

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Year:  1999        PMID： 10450420     DOI： 10.1016/s0035-9203(99)90321-8

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  44 in total

1.  Chemotherapy, within-host ecology and the fitness of drug-resistant malaria parasites.

Authors:  Silvie Huijben; William A Nelson; Andrew R Wargo; Derek G Sim; Damien R Drew; Andrew F Read
Journal:  Evolution       Date:  2010-08-19       Impact factor: 3.694

2.  Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections.

Authors:  Jesse J Kwiek; Alisa P Alker; Emily C Wenink; Marjorie Chaponda; Linda V Kalilani; Steven R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  2006-11-20       Impact factor: 5.191

3.  The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection.

Authors:  S Huijben; D G Sim; W A Nelson; A F Read
Journal:  J Evol Biol       Date:  2011-08-23       Impact factor: 2.411

4.  The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy.

Authors:  Andrew F Read; Troy Day; Silvie Huijben
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-20       Impact factor: 11.205

5.  Genetic diversity of Plasmodium falciparum merozoite surface protein-1 block 2 in sites of contrasting altitudes and malaria endemicities in the Mount Cameroon region.

Authors:  Samuel Wanji; Arnaud J Kengne-Ouafo; Ebanga E Joan Eyong; Helen K Kimbi; Nicholas Tendongfor; Judith L Ndamukong-Nyanga; Hugues C Nana-Djeunga; Catherine Bourguinat; David D Sofeu-Feugaing; Claude L Charvet
Journal:  Am J Trop Med Hyg       Date:  2012-05       Impact factor: 2.345

6.  Ahead of the curve: next generation estimators of drug resistance in malaria infections.

Authors:  Nicole Mideo; David A Kennedy; Jane M Carlton; Jeffrey A Bailey; Jonathan J Juliano; Andrew F Read
Journal:  Trends Parasitol       Date:  2013-06-05

Review 7.  Social parasites.

Authors:  Miguel A Lopez; HoangKim T Nguyen; Michael Oberholzer; Kent L Hill
Journal:  Curr Opin Microbiol       Date:  2011-10-21       Impact factor: 7.934

8.  Virulence and competitive ability in genetically diverse malaria infections.

Authors:  Jacobus C de Roode; Riccardo Pansini; Sandra J Cheesman; Michelle E H Helinski; Silvie Huijben; Andrew R Wargo; Andrew S Bell; Brian H K Chan; David Walliker; Andrew F Read
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-13       Impact factor: 11.205

9.  On the evolution of reproductive restraint in malaria.

Authors:  Nicole Mideo; Troy Day
Journal:  Proc Biol Sci       Date:  2008-05-22       Impact factor: 5.349

10.  Competition between Plasmodium falciparum strains in clinical infections during in vitro culture adaptation.

Authors:  Kexuan Chen; Ling Sun; Yingxue Lin; Qi Fan; Zhenjun Zhao; Mingming Hao; Guohua Feng; Yanrui Wu; Liwang Cui; Zhaoqing Yang
Journal:  Infect Genet Evol       Date:  2014-03-22       Impact factor: 3.342
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