| Literature DB >> 10449357 |
J Capdevila1, J C lzpisúa Belmonte.
Abstract
Localized embryonic expression of members of the Hedgehog, Wnt and TGF-beta families of secreted factors has been shown to organize pattern and provide positional information in many developing systems. Recently, several extracellular factors have been described that act either as facilitators or inhibitors of the activities of those secreted proteins. The variety of molecular strategies involved in the extracellular modulation of signalling activities in the embryo underscores the importance of maintaining a tight spatial and temporal control of the activities of organizing centers during development.Entities:
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Year: 1999 PMID： 10449357 DOI： 10.1016/s0959-437x(99)80065-3
Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578