J R Poortmans1, M Francaux. 1. Chimie Physiologique, Institut Supérieur d'Education Physique et de Kinésithérapie, Université Libre de Bruxelles, Brussels, Belgium. jrpoortm@ulb.ac.be
Abstract
PURPOSE: Oral creatine supplementation is widely used in sportsmen and women. Side effects have been postulated, but no thorough investigations have been conducted to support these assertions. It is important to know whether long-term oral creatine supplementation has any detrimental effects on kidney function in healthy population. METHODS: Creatinine, urea, and plasma albumin clearances have been determined in oral creatine consumers (10 months to 5 yr) and in a control group. RESULTS: There were no statistical differences between the control group and the creatine consumer group for plasma contents and urine excretion rates for creatinine, urea, and albumin. Clearance of these compounds did not differ between the two groups. Thus, glomerular filtration rate, tubular reabsorption, and glomerular membrane permeability were normal in both groups. CONCLUSIONS: Neither short-term, medium-term, nor long-term oral creatine supplements induce detrimental effects on the kidney of healthy individuals.
PURPOSE: Oral creatine supplementation is widely used in sportsmen and women. Side effects have been postulated, but no thorough investigations have been conducted to support these assertions. It is important to know whether long-term oral creatine supplementation has any detrimental effects on kidney function in healthy population. METHODS:Creatinine, urea, and plasma albumin clearances have been determined in oral creatine consumers (10 months to 5 yr) and in a control group. RESULTS: There were no statistical differences between the control group and the creatine consumer group for plasma contents and urine excretion rates for creatinine, urea, and albumin. Clearance of these compounds did not differ between the two groups. Thus, glomerular filtration rate, tubular reabsorption, and glomerular membrane permeability were normal in both groups. CONCLUSIONS: Neither short-term, medium-term, nor long-term oral creatine supplements induce detrimental effects on the kidney of healthy individuals.
Authors: Bruno Gualano; Vitor de Salles Painelli; Hamilton Roschel; Rebeca Lugaresi; Egidio Dorea; Guilherme Giannini Artioli; Fernanda Rodrigues Lima; Maria Elizabeth Rossi da Silva; Maria Rosária Cunha; Antonio Carlos Seguro; Maria Heloisa Shimizu; Maria Concepción García Otaduy; Marcelo Tatit Sapienza; Cláudia da Costa Leite; Eloisa Bonfá; Antonio Herbert Lancha Junior Journal: Eur J Appl Physiol Date: 2010-10-26 Impact factor: 3.078
Authors: Richard V Clark; Ann C Walker; Robin L O'Connor-Semmes; Michael S Leonard; Ram R Miller; Stephen A Stimpson; Scott M Turner; Eric Ravussin; William T Cefalu; Marc K Hellerstein; William J Evans Journal: J Appl Physiol (1985) Date: 2014-04-24