Literature DB >> 10445029

A role for transcriptional repressors in targeting the yeast Swi/Snf complex.

D Dimova1, Z Nackerdien, S Furgeson, S Eguchi, M A Osley.   

Abstract

Genetic and biochemical studies indicate that the evolutionarily conserved Swi/Snf complex acts at a subset of genes to help transcriptional activators function on chromatin templates. The mechanism by which this complex is targeted to specific chromosomal loci remains unknown. We show that Swi/Snf is required for expression of the yeast histone HTA1-HTB1 locus because of the role of Hir1p and Hir2p corepressors in negatively regulating transcription. Snf5p, Snf2p/Swi2p, and Swi3p, three components of the yeast Swi/Snf complex, coimmunoprecipitate with each Hir protein, and Snf5p is maximally associated with the HTA1-HTB1 promoter when the Hir-based repression system is intact and the Swi/Snf complex is functional. The data support a role for the Hir repressors in the gene-specific targeting of Swi/Snf.

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Year:  1999        PMID： 10445029     DOI： 10.1016/s1097-2765(00)80189-6

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  51 in total

1.  Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators.

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Journal:  Genes Dev       Date:  1999-09-15       Impact factor: 11.361

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3.  Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.

Authors:  Huck Hui Ng; François Robert; Richard A Young; Kevin Struhl
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4.  Antagonistic remodelling by Swi-Snf and Tup1-Ssn6 of an extensive chromatin region forms the background for FLO1 gene regulation.

Authors:  A B Fleming; S Pennings
Journal:  EMBO J       Date:  2001-09-17       Impact factor: 11.598

5.  Slm9, a novel nuclear protein involved in mitotic control in fission yeast.

Authors:  J Kanoh; P Russell
Journal:  Genetics       Date:  2000-06       Impact factor: 4.562

6.  Multiple roles for Saccharomyces cerevisiae histone H2A in telomere position effect, Spt phenotypes and double-strand-break repair.

Authors:  Holly R Wyatt; Hungjiun Liaw; George R Green; Arthur J Lustig
Journal:  Genetics       Date:  2003-05       Impact factor: 4.562

7.  The Swi/Snf chromatin remodeling complex is required for ribosomal DNA and telomeric silencing in Saccharomyces cerevisiae.

Authors:  Vardit Dror; Fred Winston
Journal:  Mol Cell Biol       Date:  2004-09       Impact factor: 4.272

8.  Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition.

Authors:  Jae-Hyun Yang; Yunkyoung Song; Ja-Hwan Seol; Jin Young Park; Yong-Jin Yang; Jeung-Whan Han; Hong-Duk Youn; Eun-Jung Cho
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-20       Impact factor: 11.205

9.  Replication-independent histone deposition by the HIR complex and Asf1.

Authors:  Erin M Green; Andrew J Antczak; Aaron O Bailey; Alexa A Franco; Kevin J Wu; John R Yates; Paul D Kaufman
Journal:  Curr Biol       Date:  2005-11-22       Impact factor: 10.834

10.  The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF.

Authors:  Philippe Prochasson; Laurence Florens; Selene K Swanson; Michael P Washburn; Jerry L Workman
Journal:  Genes Dev       Date:  2005-11-01       Impact factor: 11.361
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