Literature DB >> 10443895

Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase.

K Ishida1, H Mitoma, S Y Song, T Uchihara, A Inaba, S Eguchi, T Kobayashi, H Mizusawa.   

Abstract

Humoral immune response to glutamic acid decarboxylase (GAD) has been implicated in the pathogenesis of stiff-man syndrome and cerebellar ataxia, but the underlying pathomechanism is unclear. Using a whole-cell patch-clamp technique with rat cerebellar slices, we found that immunoglobulins present in the cerebrospinal fluid of an ataxic patient acted presynaptically to cause a selective suppression of GABAergic transmission. This synaptic depression was most likely elicited by an autoantibody to GAD.

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Year:  1999        PMID： 10443895

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  33 in total

1.  Cerebellar degeneration and polyglandular autoimmune syndrome with anti-glutamic acid decarboxylase antibodies.

Authors:  S Rüegg; M Stahl; M Bühlmann; A Dupont; P A Lyrer; R L Humbel; A J Steck
Journal:  J Neurol       Date:  2002-03       Impact factor: 4.849

Review 2.  Autoimmune stiff person syndrome and related myelopathies: understanding of electrophysiological and immunological processes.

Authors:  Goran Rakocevic; Mary Kay Floeter
Journal:  Muscle Nerve       Date:  2012-05       Impact factor: 3.217

3.  Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells.

Authors:  Amanda R Burton; Zachary Baquet; George S Eisenbarth; Roland Tisch; Richard Smeyne; Creg J Workman; Dario A A Vignali
Journal:  J Immunol       Date:  2010-03-26       Impact factor: 5.422

4.  Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxia.

Authors:  Kazuyuki Ishida; Hiroshi Mitoma; Yoshiaki Wada; Teruaki Oka; Junji Shibahara; Yuko Saito; Shigeo Murayama; Hidehiro Mizusawa
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-11-21       Impact factor: 10.154

5.  Intravenous immunoglobulin in patients with anti-GAD antibody-associated neurological diseases and patients with inflammatory myopathies: effects on clinicopathological features and immunoregulatory genes.

Authors:  Marinos C Dalakas
Journal:  Clin Rev Allergy Immunol       Date:  2005-12       Impact factor: 8.667

6.  GABA-A receptor impairment in cerebellar ataxia with anti-glutamic acid decarboxylase antibodies.

Authors:  Yasushi Hosoi; Makiko Suzuki-Sakao; Tatsuhiro Terada; Takashi Konishi; Yasuomi Ouchi; Hiroaki Miyajima; Satoshi Kono
Journal:  J Neurol       Date:  2013-10-05       Impact factor: 4.849

7.  Cerebellar ataxia and glutamic acid decarboxylase antibodies: immunologic profile and long-term effect of immunotherapy.

Authors:  Helena Ariño; Nuria Gresa-Arribas; Yolanda Blanco; Eugenia Martínez-Hernández; Lidia Sabater; Mar Petit-Pedrol; Idoia Rouco; Luis Bataller; Josep O Dalmau; Albert Saiz; Francesc Graus
Journal:  JAMA Neurol       Date:  2014-08       Impact factor: 18.302

8.  Stiff person syndrome: advances in pathogenesis and therapeutic interventions.

Authors:  Marinos C Dalakas
Journal:  Curr Treat Options Neurol       Date:  2009-03       Impact factor: 3.598

9.  The GABAergic septohippocampal pathway is directly involved in internal processes related to operant reward learning.

Authors:  Germán Vega-Flores; Sara E Rubio; M Teresa Jurado-Parras; María Ángeles Gómez-Climent; Christiane S Hampe; Mario Manto; Eduardo Soriano; Marta Pascual; Agnès Gruart; José M Delgado-García
Journal:  Cereb Cortex       Date:  2013-03-10       Impact factor: 5.357

10.  Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies.

Authors:  M Vianello; B Tavolato; M Armani; B Giometto
Journal:  Cerebellum       Date:  2003       Impact factor: 3.847
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