| Literature DB >> 10432709 |
C R Wagner1, S L Chang, G W Griesgraber, H Song, E J McIntee, C L Zimmerman.
Abstract
Stable and water soluble amino acid phosphomonoester amidates of AZT were synthesized and shown to have potent anti-HIV-1 activity. Intracellular and cell extract metabolism studies revealed that these compounds are likely to be enzymatically converted to the corresponding monophosphates. In addition, we have shown that the half life and tissue distribution of a phosphoramidate of AZT is 5 and 10-fold greater, respectively, than AZT.Entities:
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Year: 1999 PMID： 10432709 DOI： 10.1080/15257779908041599
Source DB: PubMed Journal: Nucleosides Nucleotides ISSN： 0732-8311