Literature DB >> 10431206

Apicomplexan plastids as drug targets.

G I McFadden1, D S Roos.   

Abstract

Prokaryotic metabolic pathways in the relict plastid of apicomplexan parasites make this organelle a promising target for drug development. The parasiticidal activity of several herbicides and antibacterial antibiotics is suspected to be a result of their ability to inhibit key plastid activities.

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Substances：

Year:  1999        PMID： 10431206     DOI： 10.1016/s0966-842x(99)01547-4

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  56 in total

1.  Triclosan and fatty acid synthesis in Plasmodium falciparum: new weapon for an old enemy.

Authors:  G P Bhat; N Surolia
Journal:  J Biosci       Date:  2001-03       Impact factor: 1.826

2.  Lateral transfer at the gene and subgenic levels in the evolution of eukaryotic enolase.

Authors:  P J Keeling; J D Palmer
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-28       Impact factor: 11.205

3.  The genomics of symbiosis: hosts keep the baby and the bath water.

Authors:  Brian Palenik
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-09       Impact factor: 11.205

4.  Multiple functionally redundant signals mediate targeting to the apicoplast in the apicomplexan parasite Toxoplasma gondii.

Authors:  Omar S Harb; Bithi Chatterjee; Martin J Fraunholz; Michael J Crawford; Manami Nishi; David S Roos
Journal:  Eukaryot Cell       Date:  2004-06

Review 5.  The apicoplast.

Authors:  Geoffrey Ian McFadden
Journal:  Protoplasma       Date:  2010-12-17       Impact factor: 3.356

Review 6.  Protein targeting into plastids: a key to understanding the symbiogenetic acquisitions of plastids.

Authors:  Ken-ichiro Ishida
Journal:  J Plant Res       Date:  2005-07-26       Impact factor: 2.629

7.  Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum.

Authors:  T N C Ramya; Satyendra Mishra; Krishanpal Karmodiya; Namita Surolia; Avadhesha Surolia
Journal:  Antimicrob Agents Chemother       Date:  2006-10-23       Impact factor: 5.191

8.  Molecular and biochemical characterization of Toxoplasma gondii beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ).

Authors:  George Dautu; Akio Ueno; Biscah Munyaka; Gabriella Carmen; Souichi Makino; Yoshiyasu Kobayashi; Makoto Igarashi
Journal:  Parasitol Res       Date:  2008-02-15       Impact factor: 2.289

9.  Parasitology as a teaching tool: isolation of apicomplexan cysts from store-bought meat.

Authors:  Tracy L Eggleston; Eileen Fitzpatrick; Kristin M Hager
Journal:  CBE Life Sci Educ       Date:  2008       Impact factor: 3.325

Review 10.  The search for the missing link: a relic plastid in Perkinsus?

Authors:  José A Fernández Robledo; Elisabet Caler; Motomichi Matsuzaki; Patrick J Keeling; Dhanasekaran Shanmugam; David S Roos; Gerardo R Vasta
Journal:  Int J Parasitol       Date:  2011-08-22       Impact factor: 3.981
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