Literature DB >> 21165662

The apicoplast.

Geoffrey Ian McFadden1.   

Abstract

Parasites like malaria and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic pathways of cyanobacterial origin. In this review, the discovery of the apicoplast and its integration, function and purpose are explored. New insights into the apicoplast fatty acid biosynthesis pathway and some novel roles of the apicoplast in vaccine development are reviewed.

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Year:  2010        PMID： 21165662     DOI： 10.1007/s00709-010-0250-5

Source DB:  PubMed          Journal:  Protoplasma        ISSN： 0033-183X            Impact factor:   3.356


  116 in total

1.  Cryptosporidium parvum appears to lack a plastid genome.

Authors:  G Zhu; M J Marchewka; J S Keithly
Journal:  Microbiology       Date:  2000-02       Impact factor: 2.777

2.  Unique properties of Plasmodium falciparum porphobilinogen deaminase.

Authors:  Viswanathan Arun Nagaraj; Rajavel Arumugam; Bulusu Gopalakrishnan; Yeleswarapu Sri Jyothsna; Pundi N Rangarajan; Govindarajan Padmanaban
Journal:  J Biol Chem       Date:  2007-10-25       Impact factor: 5.157

3.  Genetic evidence that an endosymbiont-derived endoplasmic reticulum-associated protein degradation (ERAD) system functions in import of apicoplast proteins.

Authors:  Swati Agrawal; Giel G van Dooren; Wandy L Beatty; Boris Striepen
Journal:  J Biol Chem       Date:  2009-10-06       Impact factor: 5.157

4.  Gene transfer from organelles to the nucleus: how much, what happens, and Why?

Authors: 
Journal:  Plant Physiol       Date:  1998-09       Impact factor: 8.340

5.  Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii.

Authors:  Jolly Mazumdar; Emma H Wilson; Kate Masek; Christopher A Hunter; Boris Striepen
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-18       Impact factor: 11.205

Review 6.  Fatty acid biosynthesis as a drug target in apicomplexan parasites.

Authors:  C D Goodman; G I McFadden
Journal:  Curr Drug Targets       Date:  2007-01       Impact factor: 3.465

7.  Protoporphyrinogen IX oxidase from Plasmodium falciparum is anaerobic and is localized to the mitochondrion.

Authors:  Viswanathan Arun Nagaraj; Rajavel Arumugam; Dasari Prasad; Pundi N Rangarajan; Govindarajan Padmanaban
Journal:  Mol Biochem Parasitol       Date:  2010-11       Impact factor: 1.759

8.  The genome of Cryptosporidium hominis.

Authors:  Ping Xu; Giovanni Widmer; Yingping Wang; Luiz S Ozaki; Joao M Alves; Myrna G Serrano; Daniela Puiu; Patricio Manque; Donna Akiyoshi; Aaron J Mackey; William R Pearson; Paul H Dear; Alan T Bankier; Darrell L Peterson; Mitchell S Abrahamsen; Vivek Kapur; Saul Tzipori; Gregory A Buck
Journal:  Nature       Date:  2004-10-28       Impact factor: 49.962

9.  Evolutionary pressures on apicoplast transit peptides.

Authors:  Stuart A Ralph; Bernardo J Foth; Neil Hall; Geoffrey I McFadden
Journal:  Mol Biol Evol       Date:  2004-08-18       Impact factor: 16.240

10.  The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival.

Authors:  Carrie F Brooks; Hanne Johnsen; Giel G van Dooren; Mani Muthalagi; San San Lin; Wolfgang Bohne; Karsten Fischer; Boris Striepen
Journal:  Cell Host Microbe       Date:  2009-12-31       Impact factor: 21.023
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  31 in total

1.  Unraveling the ubiquitome of the human malaria parasite.

Authors:  Nadia Ponts; Anita Saraf; Duk-Won D Chung; Alona Harris; Jacques Prudhomme; Michael P Washburn; Laurence Florens; Karine G Le Roch
Journal:  J Biol Chem       Date:  2011-09-19       Impact factor: 5.157

Review 2.  YCF1: A Green TIC?

Authors:  Jan de Vries; Filipa L Sousa; Bettina Bölter; Jürgen Soll; Sven B Gould
Journal:  Plant Cell       Date:  2015-03-27       Impact factor: 11.277

3.  Kingdom Chromista and its eight phyla: a new synthesis emphasising periplastid protein targeting, cytoskeletal and periplastid evolution, and ancient divergences.

Authors:  Thomas Cavalier-Smith
Journal:  Protoplasma       Date:  2017-09-05       Impact factor: 3.356

4.  Insights into the evolution and drug susceptibility of Babesia duncani from the sequence of its mitochondrial and apicoplast genomes.

Authors:  Azan Z Virji; Jose Thekkiniath; Wenxiu Ma; Lauren Lawres; James Knight; Andrea Swei; Karine Le Roch; Choukri Ben Mamoun
Journal:  Int J Parasitol       Date:  2018-08-31       Impact factor: 3.981

Review 5.  Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling.

Authors:  Praveen Rai; Drista Sharma; Rani Soni; Nazia Khatoon; Bhaskar Sharma; Tarun Kumar Bhatt
Journal:  J Microbiol       Date:  2017-03-01       Impact factor: 3.422

6.  Features of autophagic cell death in Plasmodium liver-stage parasites.

Authors:  Nina Eickel; Gesine Kaiser; Monica Prado; Paul-Christian Burda; Matthias Roelli; Rebecca R Stanway; Volker T Heussler
Journal:  Autophagy       Date:  2013-02-06       Impact factor: 16.016

7.  Lateral gene transfer of family A DNA polymerases between thermophilic viruses, aquificae, and apicomplexa.

Authors:  Thomas W Schoenfeld; Senthil K Murugapiran; Jeremy A Dodsworth; Sally Floyd; Michael Lodes; David A Mead; Brian P Hedlund
Journal:  Mol Biol Evol       Date:  2013-04-22       Impact factor: 16.240

8.  Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites.

Authors:  Geoffrey Ian McFadden; Christopher Dean Goodman; Taher Uddin
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

9.  Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.

Authors:  Stephen P Muench; Jozef Stec; Ying Zhou; Gustavo A Afanador; Martin J McPhillie; Mark R Hickman; Patty J Lee; Susan E Leed; Jennifer M Auschwitz; Sean T Prigge; David W Rice; Rima McLeod
Journal:  Bioorg Med Chem Lett       Date:  2013-04-24       Impact factor: 2.823

10.  Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum.

Authors:  Kei Kitamura; Chieko Kishi-Itakura; Takafumi Tsuboi; Shigeharu Sato; Kiyoshi Kita; Nobuo Ohta; Noboru Mizushima
Journal:  PLoS One       Date:  2012-08-10       Impact factor: 3.240
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