Literature DB >> 10431176

Chemical genetics: exploring and controlling cellular processes with chemical probes.

C M Crews1, U Splittgerber.   

Abstract

The new field of chemical biology brings together chemists and biologists who are seeking to understand and mimic the natural world. One research strategy in this new field is the development of biologically active small molecules as molecular probes. This approach, which has been called 'chemical' genetics, has allowed elucidation of several pathways that have been difficult to study using traditional genetic approaches.

Mesh:

Substances:

Year:  1999        PMID: 10431176     DOI: 10.1016/s0968-0004(99)01425-5

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN: 0968-0004            Impact factor:   13.807


  21 in total

1.  A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii.

Authors:  Kimberly L Carey; Nicholas J Westwood; Timothy J Mitchison; Gary E Ward
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-03       Impact factor: 11.205

2.  Revisiting the role of the immunoproteasome in the activation of the canonical NF-κB pathway.

Authors:  Eun Ryoung Jang; Na-Ra Lee; Songhee Han; Ying Wu; Lalit Kumar Sharma; Kimberly Cornish Carmony; James Marks; Do-Min Lee; Jung-Ok Ban; Marie Wehenkel; Jin Tae Hong; Kyung Bo Kim; Wooin Lee
Journal:  Mol Biosyst       Date:  2012-06-22

3.  Developing microcolin A analogs as biological probes.

Authors:  Amit K Mandal; John Hines; Kouji Kuramochi; Craig M Crews
Journal:  Bioorg Med Chem Lett       Date:  2005-09-15       Impact factor: 2.823

4.  Inverse drug screens: a rapid and inexpensive method for implicating molecular targets.

Authors:  Dany S Adams; Michael Levin
Journal:  Genesis       Date:  2006-11       Impact factor: 2.487

5.  Phenotypic high-throughput screening in atherosclerosis research: focus on macrophages.

Authors:  Anthony J Muslin
Journal:  J Cardiovasc Transl Res       Date:  2010-07-13       Impact factor: 4.132

6.  Full kinetics investigation of the formation reaction of phosphonate esters in the gas-phase: a theoretical study.

Authors:  Mohammad Amin Kazemian; Sayyed Mostafa Habibi-Khorassani; Malek Taher Maghsoodlu; Ali Ebrahimi
Journal:  J Mol Model       Date:  2014-03-16       Impact factor: 1.810

7.  Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans.

Authors:  Kurt A Toenjes; Suzanne M Munsee; Ashraf S Ibrahim; Rachel Jeffrey; John E Edwards; Douglas I Johnson
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

Review 8.  The application of phenotypic high-throughput screening techniques to cardiovascular research.

Authors:  Yoram Etzion; Anthony J Muslin
Journal:  Trends Cardiovasc Med       Date:  2009-08       Impact factor: 6.677

9.  Two-headed PROTAC: an effective new tool for targeted protein degradation.

Authors:  Kedra Cyrus; Marie Wehenkel; Eun-Young Choi; Hollie Swanson; Kyung-Bo Kim
Journal:  Chembiochem       Date:  2010-07-26       Impact factor: 3.164

10.  An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines.

Authors:  M Burnette; T Brito-Robinson; J Li; J Zartman
Journal:  Mol Biosyst       Date:  2014-10
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.