Literature DB >> 10430051

Cultured rat microglia express functional beta-chemokine receptors.

E W Boddeke1, I Meigel, S Frentzel, N G Gourmala, J K Harrison, M Buttini, O Spleiss, P Gebicke-Härter.   

Abstract

We have investigated the functional expression of the beta-chemokine receptors CCR1 to 5 in cultured rat microglia. RT-PCR analysis revealed constitutive expression of CCR1, CCR2 and CCR5 mRNA. The beta-chemokines MCP-1 (1-30 nM) as well as RANTES and MIP-1alpha (100-1000 nM) evoked calcium transients in control and LPS-treated microglia. Whereas, the response to MCP-1 was dependent on extracellular calcium the response to RANTES was not. The effect of MCP-1 but not that of RANTES was inhibited by the calcium-induced calcium release inhibitor ryanodine. Calcium responses to MCP-1- and RANTES were observed in distinct populations of microglia.

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Year:  1999        PMID： 10430051     DOI： 10.1016/s0165-5728(99)00096-x

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  34 in total

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