Literature DB >> 10419144

n-3 fatty acids in the prevention of cardiac arrhythmias.

A Leaf1, J X Kang, Y F Xiao, G E Billman.   

Abstract

In animals and probably in humans n-3 polyunsaturated fatty acids (PUFA) are antiarrhythmic. A report follows on the recent studies of the antiarrhythmic actions of PUFA. The PUFA stabilize the electrical activity of isolated cardiac myocytes by inhibiting sarcolemmal ion channels, so that a stronger electrical stimulus is required to elicit an action potential and the relative refractory period is markedly prolonged. This appears at present to be the probable major antiarrhythmic mechanism of PUFA.

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Year:  1999        PMID： 10419144     DOI： 10.1007/BF02562284

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.646


  22 in total

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10.  Protective effects of All-trans-retinoic acid against cardiac arrhythmias induced by isoproterenol, lysophosphatidylcholine or ischemia and reperfusion.

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