Literature DB >> 10419088

New developments in phospholipase A2.

B Chaminade1, F Le Balle, O Fourcade, M Nauze, C Delagebeaudeuf, A Gassama-Diagne, M F Simon, J Fauvel, H Chap.   

Abstract

Some of the most recent data concerning various phospholipases A2, with special emphasis on secretory, cytosolic, and calcium-independent phospholipases A2 are summarized. Besides their contribution to the production of proinflammatory lipid mediators, the involvement of these enzymes in key cell responses such as apoptosis or tumor cell metastatic potential is also discussed, taking advantage of transgenic models based on gene invalidation by homologous recombination. The possible role of secretory and cytosolic platelet-activating factor acetyl hydrolases is also briefly mentioned. Finally, the ectopic expression in epididymis of an intestinal phospholipase B opens some novel issues as to the possible function of phospholipases in reproduction.

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Year:  1999        PMID： 10419088     DOI： 10.1007/BF02562228

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.646


  86 in total

1.  Group II phospholipase A2 is increased in peritoneal and pleural effusions in patients with various types of cancer.

Authors:  T Abe; K Sakamoto; H Kamohara; Y Hirano; N Kuwahara; M Ogawa
Journal:  Int J Cancer       Date:  1997-06-20       Impact factor: 7.396

2.  Loss of the PLA2G2A gene in a sporadic colorectal tumor of a patient with a PLA2G2A germline mutation and absence of PLA2G2A germline alterations in patients with FAP.

Authors:  I Nimmrich; W Friedl; R Kruse; S Pietsch; S Hentsch; R Deuter; G Winde; O Müller
Journal:  Hum Genet       Date:  1997-09       Impact factor: 4.132

3.  Lysophosphatidic acid: G-protein signalling and cellular responses.

Authors:  W H Moolenaar; O Kranenburg; F R Postma; G C Zondag
Journal:  Curr Opin Cell Biol       Date:  1997-04       Impact factor: 8.382

4.  Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.

Authors:  J V Bonventre; Z Huang; M R Taheri; E O'Leary; E Li; M A Moskowitz; A Sapirstein
Journal:  Nature       Date:  1997-12-11       Impact factor: 49.962

5.  Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection.

Authors:  T C Wang; J R Goldenring; C Dangler; S Ito; A Mueller; W K Jeon; T J Koh; J G Fox
Journal:  Gastroenterology       Date:  1998-04       Impact factor: 22.682

6.  The perturbed membrane of cells undergoing apoptosis is susceptible to type II secretory phospholipase A2 to liberate arachidonic acid.

Authors:  G Atsumi; M Murakami; M Tajima; S Shimbara; N Hara; I Kudo
Journal:  Biochim Biophys Acta       Date:  1997-11-08

7.  cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase.

Authors:  K Hattori; H Adachi; A Matsuzawa; K Yamamoto; M Tsujimoto; J Aoki; M Hattori; H Arai; K Inoue
Journal:  J Biol Chem       Date:  1996-12-20       Impact factor: 5.157

8.  Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen.

Authors:  S Glover; M S de Carvalho; T Bayburt; M Jonas; E Chi; C C Leslie; M H Gelb
Journal:  J Biol Chem       Date:  1995-06-23       Impact factor: 5.157

9.  A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.

Authors:  I P Tomlinson; K Neale; I C Talbot; A D Spigelman; C B Williams; R K Phillips; W F Bodmer
Journal:  J Med Genet       Date:  1996-04       Impact factor: 6.318

10.  Overexpression of group II phospholipase A2 in human breast cancer tissues is closely associated with their malignant potency.

Authors:  S Yamashita; J Yamashita; M Ogawa
Journal:  Br J Cancer       Date:  1994-06       Impact factor: 7.640
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  3 in total

1.  Purification, characterization, and molecular cloning of group I phospholipases A2 from the gills of the red sea bream, Pagrus major.

Authors:  N Iijima; S Uchiyama; Y Fujikawa; M Esaka
Journal:  Lipids       Date:  2000-12       Impact factor: 1.880

2.  Negative regulation of cytosolic phospholipase A(2) by melatonin in the rat pineal gland.

Authors:  B Li; H Zhang; M Akbar; H Y Kim
Journal:  Biochem J       Date:  2000-11-01       Impact factor: 3.857

3.  Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2).

Authors:  Dennis A Wong; Yoshihiro Kita; Naonori Uozumi; Takao Shimizu
Journal:  J Exp Med       Date:  2002-08-05       Impact factor: 14.307
  3 in total

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