| Literature DB >> 10418338 |
K R Min, B Y Hwang, H S Lim, B S Kang, G J Oh, J Lee, S H Kang, K S Lee, J S Ro, Y Kim.
Abstract
An inhibitor of cyclooxygenase (COX)-1 activity of prostaglandin H2 synthase was isolated from aerial parts of Celastrus orbiculatus Thunb. (Celastraceae), an oriental folk medicine for rheumatoid arthritis by activity-guided column chromatographic methods. The COX inhibitor was identified as (-)-epiafzelechin, a member of flavan-3-ols by the structural analysis with HR-EI-mass, 1H-NMR and 13C-NMR spectral data. The compound exhibited a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM. (-)-Epiafzelechin exhibited about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. (-)-Epiafzelechin exhibited significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.Entities:
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Year: 1999 PMID： 10418338 DOI： 10.1055/s-2006-960813
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352