Literature DB >> 10418073

Exercise and the treatment of type 2 diabetes mellitus. An update.

J G Eriksson1.   

Abstract

Exercise has long been considered a cornerstone in the treatment regimen for patients with type 2 (non-insulin-dependent) diabetes mellitus. Aerobic endurance exercise has traditionally been advocated as the most suitable exercise mode. Several exercise studies have evaluated the effect of exercise on insulin sensitivity and glycaemic control in patients with type 2 diabetes mellitus. However, the results obtained have been highly heterogeneous regarding the effect of exercise on insulin sensitivity and glycaemic control. Only in certain subgroups (e.g. patients with type 2 diabetes mellitus under 55 years of age, those with diabetes treated through diet and those who have diabetes with fairly good metabolic control), does exercise seem to be beneficial with regard to improvement in glycaemic control. There has been little research into the effects of resistance training on glucose metabolism in patients with type 2 diabetes mellitus compared with the amount of research involving aerobic endurance exercise. The incidence of type 2 diabetes mellitus increases with increasing age, partly because of the decline in muscle mass associated with aging. This corresponds with a decline in metabolic function, supporting the usefulness of resistance training. Available studies support the usefulness of resistance training in the treatment of type 2 diabetes mellitus. Therefore, based on the published studies reviewed, this author proposes that an optimal exercise programme for individuals with type 2 diabetes mellitus should include components that improve cardiorespiratory fitness, muscular strength and endurance, i.e. a combination of aerobic endurance training and circuit-type resistance training. Programmes combining various modes of exercise positively influence patient compliance with the exercise programme. The vast majority of patients with type 2 diabetes mellitus can undertake an individualised exercise programme without significantly increased risks of complications.

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Year:  1999        PMID: 10418073     DOI: 10.2165/00007256-199927060-00003

Source DB:  PubMed          Journal:  Sports Med        ISSN: 0112-1642            Impact factor:   11.136


  55 in total

1.  Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients.

Authors:  P C Ligtenberg; J B Hoekstra; E Bol; M L Zonderland; D W Erkelens
Journal:  Clin Sci (Lond)       Date:  1997-08       Impact factor: 6.124

2.  Glucose metabolism during leg exercise in man.

Authors:  J Wahren; P Felig; G Ahlborg; L Jorfeldt
Journal:  J Clin Invest       Date:  1971-12       Impact factor: 14.808

3.  Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men.

Authors:  R Pratley; B Nicklas; M Rubin; J Miller; A Smith; M Smith; B Hurley; A Goldberg
Journal:  J Appl Physiol (1985)       Date:  1994-01

Review 4.  Overview of diabetes mellitus and exercise.

Authors:  J M Ekoé
Journal:  Med Sci Sports Exerc       Date:  1989-08       Impact factor: 5.411

5.  Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance?

Authors:  J Eriksson; J Tuominen; T Valle; S Sundberg; A Sovijärvi; H Lindholm; J Tuomilehto; V Koivisto
Journal:  Horm Metab Res       Date:  1998-01       Impact factor: 2.936

6.  Exercise therapy of non-insulin dependent diabetes mellitus a report of 10 year studies. The efficacy of exercise therapy.

Authors:  G X Di; W P Teng; J Zhang; P Y Fu
Journal:  Chin Med J (Engl)       Date:  1993-10       Impact factor: 2.628

7.  Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids.

Authors:  G Ahlborg; P Felig; L Hagenfeldt; R Hendler; J Wahren
Journal:  J Clin Invest       Date:  1974-04       Impact factor: 14.808

8.  Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus.

Authors:  S H Schneider; A K Khachadurian; L F Amorosa; L Clemow; N B Ruderman
Journal:  Diabetes Care       Date:  1992-11       Impact factor: 19.112

Review 9.  Effects of exercise on insulin sensitivity in humans.

Authors:  J T Devlin
Journal:  Diabetes Care       Date:  1992-11       Impact factor: 19.112

10.  Effects of resistance exercise on glucose tolerance in normal and glucose-intolerant subjects.

Authors:  J D Fluckey; M S Hickey; J K Brambrink; K K Hart; K Alexander; B W Craig
Journal:  J Appl Physiol (1985)       Date:  1994-09
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  13 in total

1.  Walking decreased risk of cardiovascular disease mortality in older adults with diabetes.

Authors:  Tyler C Smith; Deborah L Wingard; Besa Smith; Donna Kritz-Silverstein; Elizabeth Barrett-Connor
Journal:  J Clin Epidemiol       Date:  2006-10-02       Impact factor: 6.437

2.  The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes.

Authors:  Philip L Hooper; Gabor Balogh; Eric Rivas; Kylie Kavanagh; Laszlo Vigh
Journal:  Cell Stress Chaperones       Date:  2014-02-13       Impact factor: 3.667

3.  Cycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers.

Authors:  Charles A Stuart; Mary E A Howell; Jonathan D Baker; Rhesa J Dykes; Michelle M Duffourc; Michael W Ramsey; Michael H Stone
Journal:  Med Sci Sports Exerc       Date:  2010-01       Impact factor: 5.411

4.  Pioglitazone improves metabolic markers in patients with type 2 diabetes independently from physical activities: results from the IRIS III study.

Authors:  Thomas Schöndorf; Andreas Pfützner; Georg Lübben; Efstrathios Karagiannis; Werner Roth; Thomas Forst
Journal:  J Diabetes Sci Technol       Date:  2008-03

5.  Insulin responsiveness in metabolic syndrome after eight weeks of cycle training.

Authors:  Charles A Stuart; Mark A South; Michelle L Lee; Melanie P McCurry; Mary E A Howell; Michael W Ramsey; Michael H Stone
Journal:  Med Sci Sports Exerc       Date:  2013-11       Impact factor: 5.411

Review 6.  Exaggerated exercise pressor reflex in type 2 diabetes: Potential role of oxidative stress.

Authors:  Ann-Katrin Grotle; Audrey J Stone
Journal:  Auton Neurosci       Date:  2019-10-21       Impact factor: 3.145

7.  Diet, exercise or diet with exercise: comparing the effectiveness of treatment options for weight-loss and changes in fitness for adults (18-65 years old) who are overfat, or obese; systematic review and meta-analysis.

Authors:  James E Clark
Journal:  J Diabetes Metab Disord       Date:  2015-04-17

8.  An overview of the contribution of fatness and fitness factors, and the role of exercise, in the formation of health status for individuals who are overweight.

Authors:  James E Clark
Journal:  J Diabetes Metab Disord       Date:  2012-10-11

Review 9.  Dietary advice for treatment of type 2 diabetes mellitus in adults.

Authors:  L Nield; H J Moore; L Hooper; J K Cruickshank; A Vyas; V Whittaker; C D Summerbell
Journal:  Cochrane Database Syst Rev       Date:  2007-07-18

10.  Diabetes alters contraction-induced mitogen activated protein kinase activation in the rat soleus and plantaris.

Authors:  A Katta; D L Preston; S K Karkala; S Asano; S Meduru; S P Mupparaju; E Yokochi; Kevin M Rice; D H Desai; E R Blough
Journal:  Exp Diabetes Res       Date:  2008
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