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Literature DB >> 10416380

A different mode of entry by dengue-2 neutralisation escape mutant virus.

Abstract

Entry processes were compared between dengue-2 (DEN-2) virus and a DEN-2 neutralisation escape mutant virus in baby hamster kidney (BHK) cells. The mutant virus (mu6B2) was resistant to neutralisation by a monoclonal antibody, MAb 6B2. Infection of BHK cells by the wild-type DEN-2 virus resulted in direct penetration of the virions into the cytoplasm whereas the mutant virus entered cells by endocytosis. The continual presence of the monoclonal antibody might have asserted some pressure for the mutant to adopt a different mode of entry.

Entities: Disease

Mesh：

Substances：
Antibodies, Monoclonal

Year: 1999 PMID： 10416380 DOI： 10.1007/s007050050561

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

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Cited

14 in total

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Authors: Karen Clyde; Jennifer L Kyle; Eva Harris
Journal: J Virol Date: 2006-08-23 Impact factor: 5.103

2. Rab 5 is required for the cellular entry of dengue and West Nile viruses.

Authors: Manoj N Krishnan; Bindu Sukumaran; Utpal Pal; Herve Agaisse; James L Murray; Thomas W Hodge; Erol Fikrig
Journal: J Virol Date: 2007-02-14 Impact factor: 5.103

3. Attenuating mutations in coxsackievirus B3 map to a conformational epitope that comprises the puff region of VP2 and the knob of VP3.

Authors: E Stadnick; M Dan; A Sadeghi; J K Chantler
Journal: J Virol Date: 2004-12 Impact factor: 5.103

A different mode of entry by dengue-2 neutralisation escape mutant virus.

Review 1. Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis.

2. Rab 5 is required for the cellular entry of dengue and West Nile viruses.

3. Attenuating mutations in coxsackievirus B3 map to a conformational epitope that comprises the puff region of VP2 and the knob of VP3.

Review 4. Dissecting vectorial capacity for mosquito-borne viruses.

5. Both E protein glycans adversely affect dengue virus infectivity but are beneficial for virion release.

6. Insights into the internalization and retrograde trafficking of Dengue 2 virus in BHK-21 cells.

Review 7. Progress in the identification of dengue virus entry/fusion inhibitors.

8. Characterization of dengue virus entry into HepG2 cells.

9. Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells.

10. Human apolipoprotein A-I is associated with dengue virus and enhances virus infection through SR-BI.